دورية أكاديمية
B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells.
| العنوان: | B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells. |
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| المؤلفون: | May KF Jr; Department of Pathology, Divisions of Cancer Immunology and Dermatology, Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, OH 43210, USA., Chang X, Zhang H, Lute KD, Zhou P, Kocak E, Zheng P, Liu Y |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2007 Feb 01; Vol. 178 (3), pp. 1542-52. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print Cited Medium: Print ISSN: 0022-1767 (Print) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Immune Tolerance*, Antigens, CD/*metabolism , Antigens, Differentiation/*metabolism , B7-1 Antigen/*physiology , T-Lymphocytes/*immunology , T-Lymphocytes, Regulatory/*physiology, Adoptive Transfer ; Animals ; Autoimmunity ; B7-1 Antigen/genetics ; B7-1 Antigen/metabolism ; CTLA-4 Antigen ; Cell Proliferation ; Inflammation ; Lymphocyte Activation ; Mice ; Mice, Knockout ; T-Lymphocytes/pathology ; T-Lymphocytes/transplantation ; T-Lymphocytes, Regulatory/transplantation |
| مستخلص: | CD4(+)CD25(+) regulatory T cells (Tregs) suppress immunity to infections and tumors as well as autoimmunity and graft-vs-host disease. Since Tregs constitutively express CTLA-4 and activated T cells express B7-1 and B7-2, it has been suggested that the interaction between CTLA-4 on Tregs and B7-1/2 on the effector T cells may be required for immune suppression. In this study, we report that autopathogenic T cells from B7-deficient mice cause multiorgan inflammation when adoptively transferred into syngeneic RAG-1-deficient hosts. More importantly, this inflammation is suppressed by adoptive transfer of purified wild-type (WT) CD4(+)CD25(+) T cells. WT Tregs also inhibited lymphoproliferation and acquisition of activation markers by the B7-deficient T cells. An in vitro suppressor assay revealed that WT and B7-deficient T cells are equally susceptible to WT Treg regulation. These results demonstrate that B7-deficient T cells are highly susceptible to immune suppression by WT Tregs and refute the hypothesis that B7-CTLA-4 interaction between effector T cells and Tregs plays an essential role in Treg function. |
| معلومات مُعتمدة: | AI51342 United States AI NIAID NIH HHS; CA12001 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Antigens, CD) 0 (Antigens, Differentiation) 0 (B7-1 Antigen) 0 (CTLA-4 Antigen) 0 (Ctla4 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20070124 Date Completed: 20070327 Latest Revision: 20190516 |
| رمز التحديث: | 20231215 |
| DOI: | 10.4049/jimmunol.178.3.1542 |
| PMID: | 17237403 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0022-1767 |
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| DOI: | 10.4049/jimmunol.178.3.1542 |