دورية أكاديمية
Necrotizing fasciitis as a late complication of multimodal treatment for locally advanced head and neck cancer: a case report.
| العنوان: | Necrotizing fasciitis as a late complication of multimodal treatment for locally advanced head and neck cancer: a case report. |
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| المؤلفون: | Maluf FC; Oncology Center, Hospital Sírio-Libanês, São Paulo, Brazil. maluffc@uol.com.br, William WN Jr, Rigato O, Menon AD, Parise O Jr, Docema MF |
| المصدر: | Head & neck [Head Neck] 2007 Jul; Vol. 29 (7), pp. 700-4. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: John Wiley And Sons Country of Publication: United States NLM ID: 8902541 Publication Model: Print Cited Medium: Print ISSN: 1043-3074 (Print) Linking ISSN: 10433074 NLM ISO Abbreviation: Head Neck Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : John Wiley And Sons Original Publication: New York, NY : J. Wiley, c1989- |
| مواضيع طبية MeSH: | Carcinoma, Squamous Cell/*therapy , Fasciitis, Necrotizing/*etiology , Oropharyngeal Neoplasms/*therapy, Anti-Bacterial Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Squamous Cell/pathology ; Debridement ; Fasciitis, Necrotizing/therapy ; Humans ; Male ; Middle Aged ; Neck/microbiology ; Neck/surgery ; Neoadjuvant Therapy/adverse effects ; Oropharyngeal Neoplasms/pathology ; Radiotherapy, Adjuvant/adverse effects ; Shock, Septic/microbiology ; Tongue/microbiology ; Tongue/surgery |
| مستخلص: | Background: Late complications of novel organ preservation multimodal protocols for the treatment of locally advanced head and neck cancer may be underreported in the literature. Methods and Results: We present the case of a 64-year-old man with T4 N0 M0 squamous cell carcinoma of the oropharynx, who enrolled on an organ-preservation protocol at our institution. He received 2 cycles of neoadjuvant chemotherapy with capecitabine, docetaxel, and carboplatin, followed by 2 more identical cycles given concurrently with radiotherapy. Nine months later, he was admitted to the hospital with Streptococcus pyogenes necrotizing fasciitis of the cervical region, leading to rapidly progressive septic shock. Conclusions: Severe infectious complications of chemoradiation for locally advanced head and neck cancer may occur months after completion of treatment. The recognition of these late side effects is crucial so as to accurately ascertain the long-term morbidity and benefits of organ-preservation protocols in this setting. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20070126 Date Completed: 20070927 Latest Revision: 20070618 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/hed.20558 |
| PMID: | 17252595 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1043-3074 |
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| DOI: | 10.1002/hed.20558 |