دورية أكاديمية
Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression.
| العنوان: | Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. |
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| المؤلفون: | Hodgson RA; Department of Neurobiology, Schering Plough Research Institute, Kenilworth, NJ 07033, USA. robert.hodgson@spcorp.com, Higgins GA, Guthrie DH, Lu SX, Pond AJ, Mullins DE, Guzzi MF, Parker EM, Varty GB |
| المصدر: | Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2007 Mar; Vol. 86 (3), pp. 431-40. Date of Electronic Publication: 2007 Jan 09. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0367050 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0091-3057 (Print) Linking ISSN: 00913057 NLM ISO Abbreviation: Pharmacol Biochem Behav Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Original Publication: Phoenix, N. Y. Ankho International, ltd. |
| مواضيع طبية MeSH: | Antidiuretic Hormone Receptor Antagonists*, Anxiety/*drug therapy , Depression/*drug therapy , Indoles/*pharmacology , Pyrimidines/*pharmacology , Pyrroles/*pharmacology , Pyrrolidines/*pharmacology , Receptors, Corticotropin-Releasing Hormone/*antagonists & inhibitors, Animals ; Anxiety/metabolism ; Anxiety/psychology ; Conditioning, Psychological/drug effects ; Depression/metabolism ; Depression/psychology ; Female ; Guinea Pigs ; Humans ; Male ; Maze Learning/drug effects ; Mice ; Rats ; Receptors, Corticotropin-Releasing Hormone/metabolism ; Receptors, Vasopressin/metabolism ; Vocalization, Animal/drug effects |
| مستخلص: | Vasopressin and corticotropin releasing factor (CRF) are both critical regulators of an animal's stress response and have been linked to anxiety and depression. As such, antagonists of the CRF1 and V1b receptor subtypes are being developed as potential treatments for affective disorders. The two most characterized V1b and CRF1 antagonists are SSR149415 and CP-154,526, respectively, and the present studies were designed to compare these two compounds in acute animal models of affective disorders. We employed five anxiety models: Separation-induced pup vocalizations (guinea pig and rat), elevated plus-maze (EPM), conditioned lick suppression (CLS), and marble burying (mouse); as well as three depression models: forced swim test (FST; mouse and rat) and tail suspension test (TST; mouse). SSR149415 (1-30 mg/kg) was active in the vocalization, EPM and CLS models, but inactive in marble burying. CP-154,526 (1-30 mg/kg) was active in vocalization models, but inactive in EPM, CLS, and marble burying. SSR149415 was inactive in all depression models; CP-154,526 was active in rat FST but inactive in mouse models. This work demonstrates the different profiles of V1b and CRF1 receptor antagonists and supports both approaches in the treatment of affective disorders. |
| المشرفين على المادة: | 0 (1-(5-chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl)-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide) 0 (Antidiuretic Hormone Receptor Antagonists) 0 (CP 154526) 0 (Indoles) 0 (Pyrimidines) 0 (Pyrroles) 0 (Pyrrolidines) 0 (Receptors, Corticotropin-Releasing Hormone) 0 (Receptors, Vasopressin) 5CLY6W2H1M (CRF receptor type 1) |
| تواريخ الأحداث: | Date Created: 20070213 Date Completed: 20070522 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.pbb.2006.12.021 |
| PMID: | 17291571 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0091-3057 |
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| DOI: | 10.1016/j.pbb.2006.12.021 |