دورية أكاديمية
Assembly of 4-aminoquinolines via palladium catalysis: a mild and convenient alternative to SNAr methodology.
| العنوان: | Assembly of 4-aminoquinolines via palladium catalysis: a mild and convenient alternative to SNAr methodology. |
|---|---|
| المؤلفون: | Margolis BJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA. margolis_brandon_j@lilly.com, Long KA, Laird DL, Ruble JC, Pulley SR |
| المصدر: | The Journal of organic chemistry [J Org Chem] 2007 Mar 16; Vol. 72 (6), pp. 2232-5. Date of Electronic Publication: 2007 Feb 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0022-3263 (Print) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Columbus Oh : American Chemical Society Original Publication: Easton, Pa. [etc.] |
| مواضيع طبية MeSH: | Aminoquinolines/*chemical synthesis, Amines/chemistry ; Catalysis ; Methods ; Palladium/chemistry ; Quinolines/chemistry |
| مستخلص: | 4-aminoquinolines, classically prepared via SNAr chemistry from an amine and 4-haloquinoline, are important scaffolds in medicinal chemistry. Interest in these compounds prompted us to explore palladium catalysis as an alternative to the existing methods for their preparation. Initial results followed by an iterative screening paradigm confirmed Pd(OAc)2/DPEphos/K3PO4 as a mild and convenient alternative for the formation of the C-N bond in 4-aminoquinolines. A description of the screen and the scope of this methodology are discussed herein. |
| المشرفين على المادة: | 0 (Amines) 0 (Aminoquinolines) 0 (Quinolines) 5TWQ1V240M (Palladium) E66400VT9R (quinoline) |
| تواريخ الأحداث: | Date Created: 20070214 Date Completed: 20070531 Latest Revision: 20131121 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1021/jo062168u |
| PMID: | 17295543 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 0022-3263 |
|---|---|
| DOI: | 10.1021/jo062168u |