دورية أكاديمية
An approach to the management of paroxysmal laryngospasm.
| العنوان: | An approach to the management of paroxysmal laryngospasm. |
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| المؤلفون: | Obholzer RJ; Department of Otorhinolaryngology, Charing Cross Hospital, London, UK. robholzer@waitrose.com, Nouraei SA, Ahmed J, Kadhim MR, Sandhu GS |
| المصدر: | The Journal of laryngology and otology [J Laryngol Otol] 2008 Jan; Vol. 122 (1), pp. 57-60. Date of Electronic Publication: 2007 Feb 26. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cambridge University Press Country of Publication: England NLM ID: 8706896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-5460 (Electronic) Linking ISSN: 00222151 NLM ISO Abbreviation: J Laryngol Otol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cambridge : Cambridge University Press Original Publication: London : Headley Brothers, |
| مواضيع طبية MeSH: | Laryngismus/*drug therapy, Adult ; Aged ; Aged, 80 and over ; Botulinum Toxins, Type A/therapeutic use ; Female ; Gastroesophageal Reflux/complications ; Humans ; Laryngismus/etiology ; Male ; Middle Aged ; Neuromuscular Agents/therapeutic use ; Proton Pump Inhibitors/therapeutic use ; Retrospective Studies ; Risk Factors ; Treatment Outcome |
| مستخلص: | Objective: To review the presentation, risk factors and management of paroxysmal laryngospasm. Study Design: Retrospective review of cases. Setting: A teaching hospital otolaryngology department with a subspecialty interest in airway disorders. Patients: All patients diagnosed with laryngospasm over a two-year period were reviewed. Information was obtained about disease presentation, risk factors, management and symptom resolution. Results: Laryngospasm was diagnosed in nine women and six men. The average age at presentation was 56+/-6.5 years, and there was an 80 per cent association with gastroesophageal reflux disease. Proton pump inhibitors led to complete symptom resolution in six patients and to partial symptomatic relief, requiring no further treatment, in a further four patients. Of the remaining five patients unresponsive to proton pump inhibitor therapy, two continued to experience syncopal episodes due to laryngospasm. Both these patients achieved complete remission after laryngeal botulinum toxin injection. Symptoms recurred after three to four months and were successfully treated with a repeat injection. Conclusions: The primary risk factor for spontaneous laryngospasm is laryngopharyngeal reflux. Symptoms are distressing and may be relieved in most cases by treatment aimed at suppressing gastric acid secretion. Laryngeal botulinum toxin injection appears to be a viable treatment modality in selected patients with refractory symptoms. |
| التعليقات: | Comment in: J Laryngol Otol. 2009 Aug;123(8):937; author reply 937-8. (PMID: 18588735) |
| المشرفين على المادة: | 0 (Neuromuscular Agents) 0 (Proton Pump Inhibitors) EC 3.4.24.69 (Botulinum Toxins, Type A) |
| تواريخ الأحداث: | Date Created: 20070227 Date Completed: 20080306 Latest Revision: 20101118 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1017/S0022215107005907 |
| PMID: | 17319986 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1748-5460 |
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| DOI: | 10.1017/S0022215107005907 |