دورية أكاديمية
أعرض في EDS

Risk factors of ototoxicity after cisplatin-based chemo-irradiation in patients with locally advanced head-and-neck cancer: a multivariate analysis.

التفاصيل البيبلوغرافية
العنوان: Risk factors of ototoxicity after cisplatin-based chemo-irradiation in patients with locally advanced head-and-neck cancer: a multivariate analysis.
المؤلفون: Zuur CL; Department of Otorhinolaryngology, Academical Medical Centre, Amsterdam, The Netherlands. cl.zuur@vumc.nl, Simis YJ, Lansdaal PE, Hart AA, Rasch CR, Schornagel JH, Dreschler WA, Balm AJ
المصدر: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2007 Aug 01; Vol. 68 (5), pp. 1320-5. Date of Electronic Publication: 2007 Apr 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0360-3016 (Print) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Elsevier, Inc
Original Publication: Elmsford, N. Y., Pergamon Press.
مواضيع طبية MeSH: Antineoplastic Agents/*adverse effects , Carcinoma, Squamous Cell/*therapy , Cisplatin/*adverse effects , Head and Neck Neoplasms/*therapy , Hearing Loss, Sensorineural/*etiology, Age Factors ; Antidotes/therapeutic use ; Antineoplastic Agents/administration & dosage ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/radiotherapy ; Cisplatin/administration & dosage ; Combined Modality Therapy/methods ; Female ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/radiotherapy ; Hearing/drug effects ; Hearing/radiation effects ; Hearing Loss, Sensorineural/chemically induced ; Humans ; Infusions, Intra-Arterial ; Male ; Middle Aged ; Multivariate Analysis ; Prospective Studies ; Radiation Dosage ; Risk Factors ; Thiosulfates/therapeutic use
مستخلص: Purpose: Cisplatin chemo-irradiation is increasingly used in locally advanced squamous cell carcinoma of the head and neck. The objective of this study is to determine risk factors of ototoxicity due to intra-arterial high-dose cisplatin chemoradiation.
Methods and Materials: A prospective analysis of hearing thresholds at low and (ultra) high frequencies obtained before, during, and after treatment in 146 patients. Treatment consisted of intra-arterial infusion of high-dose cisplatin (150 mg/m(2), four courses) with sodium thiosulfate rescue and concurrent radiation therapy (70 Gy). Patient and chemoradiation variables were studied in a multivariate analysis.
Results: After treatment, 23% of the ears were under consideration for hearing aids because of therapy. Twenty-two percent of the patients developed an increase in air-bone gap >10 dB during or after therapy. In the multivariate explanatory analysis, cumulative dose of cisplatin and radiation therapy, and young age displayed a causal relationship with increased sensorineural hearing loss during and after therapy (p < 0.001). In the multivariate prediction analysis, pretreatment hearing level of the concerning ear was identified as an independent predictive factor for hearing capability after therapy (p < 0.0001).
Conclusions: Both cisplatin and radiation therapy were proven to induce sensorineural hearing loss, in this study with short-term follow-up. Of all patient and treatment variables studied, the patients pretreatment hearing level appeared to be the main predictive factor for hearing capability after high-dose intra-arterial cisplatin chemoradiation.
المشرفين على المادة: 0 (Antidotes)
0 (Antineoplastic Agents)
0 (Thiosulfates)
HX1032V43M (sodium thiosulfate)
Q20Q21Q62J (Cisplatin)
تواريخ الأحداث: Date Created: 20070410 Date Completed: 20071009 Latest Revision: 20151119
رمز التحديث: 20240628
DOI: 10.1016/j.ijrobp.2007.01.042
PMID: 17418969
قاعدة البيانات: MEDLINE
الوصف
تدمد:0360-3016
DOI:10.1016/j.ijrobp.2007.01.042