دورية أكاديمية
Risk factors of ototoxicity after cisplatin-based chemo-irradiation in patients with locally advanced head-and-neck cancer: a multivariate analysis.
العنوان: | Risk factors of ototoxicity after cisplatin-based chemo-irradiation in patients with locally advanced head-and-neck cancer: a multivariate analysis. |
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المؤلفون: | Zuur CL; Department of Otorhinolaryngology, Academical Medical Centre, Amsterdam, The Netherlands. cl.zuur@vumc.nl, Simis YJ, Lansdaal PE, Hart AA, Rasch CR, Schornagel JH, Dreschler WA, Balm AJ |
المصدر: | International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2007 Aug 01; Vol. 68 (5), pp. 1320-5. Date of Electronic Publication: 2007 Apr 06. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0360-3016 (Print) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE |
أسماء مطبوعة: | Publication: New York, NY : Elsevier, Inc Original Publication: Elmsford, N. Y., Pergamon Press. |
مواضيع طبية MeSH: | Antineoplastic Agents/*adverse effects , Carcinoma, Squamous Cell/*therapy , Cisplatin/*adverse effects , Head and Neck Neoplasms/*therapy , Hearing Loss, Sensorineural/*etiology, Age Factors ; Antidotes/therapeutic use ; Antineoplastic Agents/administration & dosage ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/radiotherapy ; Cisplatin/administration & dosage ; Combined Modality Therapy/methods ; Female ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/radiotherapy ; Hearing/drug effects ; Hearing/radiation effects ; Hearing Loss, Sensorineural/chemically induced ; Humans ; Infusions, Intra-Arterial ; Male ; Middle Aged ; Multivariate Analysis ; Prospective Studies ; Radiation Dosage ; Risk Factors ; Thiosulfates/therapeutic use |
مستخلص: | Purpose: Cisplatin chemo-irradiation is increasingly used in locally advanced squamous cell carcinoma of the head and neck. The objective of this study is to determine risk factors of ototoxicity due to intra-arterial high-dose cisplatin chemoradiation. Methods and Materials: A prospective analysis of hearing thresholds at low and (ultra) high frequencies obtained before, during, and after treatment in 146 patients. Treatment consisted of intra-arterial infusion of high-dose cisplatin (150 mg/m(2), four courses) with sodium thiosulfate rescue and concurrent radiation therapy (70 Gy). Patient and chemoradiation variables were studied in a multivariate analysis. Results: After treatment, 23% of the ears were under consideration for hearing aids because of therapy. Twenty-two percent of the patients developed an increase in air-bone gap >10 dB during or after therapy. In the multivariate explanatory analysis, cumulative dose of cisplatin and radiation therapy, and young age displayed a causal relationship with increased sensorineural hearing loss during and after therapy (p < 0.001). In the multivariate prediction analysis, pretreatment hearing level of the concerning ear was identified as an independent predictive factor for hearing capability after therapy (p < 0.0001). Conclusions: Both cisplatin and radiation therapy were proven to induce sensorineural hearing loss, in this study with short-term follow-up. Of all patient and treatment variables studied, the patients pretreatment hearing level appeared to be the main predictive factor for hearing capability after high-dose intra-arterial cisplatin chemoradiation. |
المشرفين على المادة: | 0 (Antidotes) 0 (Antineoplastic Agents) 0 (Thiosulfates) HX1032V43M (sodium thiosulfate) Q20Q21Q62J (Cisplatin) |
تواريخ الأحداث: | Date Created: 20070410 Date Completed: 20071009 Latest Revision: 20151119 |
رمز التحديث: | 20240628 |
DOI: | 10.1016/j.ijrobp.2007.01.042 |
PMID: | 17418969 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0360-3016 |
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DOI: | 10.1016/j.ijrobp.2007.01.042 |