دورية أكاديمية
Oral phosphodiesterase-5 inhibitors: effect of heme oxygenase inhibition on cGMP signalling in rat cavernous tissue.
| العنوان: | Oral phosphodiesterase-5 inhibitors: effect of heme oxygenase inhibition on cGMP signalling in rat cavernous tissue. |
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| المؤلفون: | Abdel Aziz MT; Molecular Biology Unit, Department of Medical Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt., Mostafa T, Atta H, Rashed L, Marzouk SA, Obaia EM, Sabry D, Hassouna AA, El-Shehaby AM, Abdel Aziz AT |
| المصدر: | Andrologia [Andrologia] 2007 Apr; Vol. 39 (2), pp. 66-70. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Pub Country of Publication: Germany NLM ID: 0423506 Publication Model: Print Cited Medium: Print ISSN: 0303-4569 (Print) Linking ISSN: 03034569 NLM ISO Abbreviation: Andrologia Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: Berlin, Grosse |
| مواضيع طبية MeSH: | 3',5'-Cyclic-GMP Phosphodiesterases/*antagonists & inhibitors , Cyclic GMP/*metabolism , Heme Oxygenase (Decyclizing)/*drug effects , Penis/*drug effects , Phosphodiesterase Inhibitors/*pharmacology, Animals ; Carbolines/pharmacology ; Cyclic Nucleotide Phosphodiesterases, Type 5 ; Imidazoles/pharmacology ; Male ; Penis/metabolism ; Piperazines/pharmacology ; Purines/pharmacology ; Rats ; Rats, Sprague-Dawley ; Sildenafil Citrate ; Sulfones/pharmacology ; Tadalafil ; Triazines/pharmacology ; Vardenafil Dihydrochloride |
| مستخلص: | This work postulated that heme oxygenase (HO) is partly responsible for controlling phosphodiesterase-5 inhibitor actions by modulating cyclic guanosine monophosphate (cGMP) cavernous tissue levels. Five hundred and four male Sprague-Dawley rats, divided into five groups, were investigated. Group 1 (n=72) included controls, group 2 (n=72) received sildenafil citrate (Viagra) orally, group 3 (n=72) received vardenafil hydrochloride (Levitra), group 4 (n=72) received tadalafil (Cialis). Group 5 (n=216), subdivided into three subgroups (A, B and C, 72 each), received the same dose of each drug with the HO inhibitor, Zn protoporphyrin. Eight rats from each group/subgroup were killed at 0.5, 1, 2, 3, 4, 6, 18, 24 and 36 h when cGMP levels in the cavernous tissues were estimated. Cavernous tissue cGMP levels increased significantly in sildenafil, vardenafil and tadalafil-treated rats compared to the controls with significant decreases after HO inhibition. It is concluded that the effects of these PDE-5 inhibitors in rat cavernous tissue are partly mediated through HO activity via the cGMP signalling pathway. |
| المشرفين على المادة: | 0 (Carbolines) 0 (Imidazoles) 0 (Phosphodiesterase Inhibitors) 0 (Piperazines) 0 (Purines) 0 (Sulfones) 0 (Triazines) 5O8R96XMH7 (Vardenafil Dihydrochloride) 742SXX0ICT (Tadalafil) BW9B0ZE037 (Sildenafil Citrate) EC 1.14.14.18 (Heme Oxygenase (Decyclizing)) EC 3.1.4.35 (3',5'-Cyclic-GMP Phosphodiesterases) EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 5) EC 3.1.4.35 (Pde5a protein, rat) H2D2X058MU (Cyclic GMP) |
| تواريخ الأحداث: | Date Created: 20070414 Date Completed: 20070613 Latest Revision: 20161124 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/j.1439-0272.2007.00765.x |
| PMID: | 17430426 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0303-4569 |
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| DOI: | 10.1111/j.1439-0272.2007.00765.x |