دورية أكاديمية
Trypanosoma brucei: peptide mapping of partially homologous variable surface glycoproteins.
| العنوان: | Trypanosoma brucei: peptide mapping of partially homologous variable surface glycoproteins. |
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| المؤلفون: | Oluoch EA; Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164., Magnuson NS, McGuire TC, Barbet AF |
| المصدر: | International journal for parasitology [Int J Parasitol] 1991 Sep; Vol. 21 (5), pp. 573-8. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 0314024 Publication Model: Print Cited Medium: Print ISSN: 0020-7519 (Print) Linking ISSN: 00207519 NLM ISO Abbreviation: Int J Parasitol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Original Publication: Oxford, New York, Pergamon Press. |
| مواضيع طبية MeSH: | Trypanosoma brucei brucei/*chemistry , Variant Surface Glycoproteins, Trypanosoma/*chemistry, Animals ; Chromatography, High Pressure Liquid ; Electrophoresis, Polyacrylamide Gel ; Peptide Mapping |
| مستخلص: | Antigenic variation in Trypanosoma brucei is caused by amino acid sequence changes in a major surface glycoprotein. Each trypanosome may contain between 100 and 1000 genes coding for this glycoprotein. Some of these genes are members of partially homologous gene families. In addition, segments of different genes may combine to form 'hybrid' or 'mosaic' genes. Thus, surface glycoproteins exist containing varying amounts of amino acid sequence homology. For investigations of molecular mechanisms of antigenic diversity it is important to identify sub-sets of trypanosomes expressing related surface glycoproteins. We describe here a simple method based on trypanosome surface labeling followed by peptide mapping to indicate homologous peptides present in one sub-set of T. brucei surface glycoproteins. |
| معلومات مُعتمدة: | R01 AI 22614 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Variant Surface Glycoproteins, Trypanosoma) |
| تواريخ الأحداث: | Date Created: 19910901 Date Completed: 19920113 Latest Revision: 20190824 |
| رمز التحديث: | 20221208 |
| DOI: | 10.1016/0020-7519(91)90062-c |
| PMID: | 1743853 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0020-7519 |
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| DOI: | 10.1016/0020-7519(91)90062-c |