دورية أكاديمية
Intraoperative gamma detection probe with presurgical antibody imaging in colon cancer.
| العنوان: | Intraoperative gamma detection probe with presurgical antibody imaging in colon cancer. |
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| المؤلفون: | Kuhn JA; Department of Surgery, City of Hope National Medical Center, Duarte, Calif. 91010., Corbisiero RM, Buras RR, Carroll RG, Wagman LD, Wilson LA, Yamauchi D, Smith MM, Kondo R, Beatty JD |
| المصدر: | Archives of surgery (Chicago, Ill. : 1960) [Arch Surg] 1991 Nov; Vol. 126 (11), pp. 1398-403. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Association Country of Publication: United States NLM ID: 9716528 Publication Model: Print Cited Medium: Print ISSN: 0004-0010 (Print) Linking ISSN: 00040010 NLM ISO Abbreviation: Arch Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chicago : American Medical Association, c1960- |
| مواضيع طبية MeSH: | Antibodies, Monoclonal*, Abdominal Neoplasms/*diagnostic imaging , Carcinoembryonic Antigen/*immunology , Colonic Neoplasms/*diagnostic imaging , Neoplasm Recurrence, Local/*diagnostic imaging, Abdominal Neoplasms/secondary ; Aged ; Colonic Neoplasms/surgery ; Female ; Humans ; Indium Radioisotopes ; Intraoperative Period ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Recurrence, Local/surgery ; Neoplasms, Unknown Primary/diagnostic imaging ; Reoperation ; Scintillation Counting/instrumentation ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed |
| مستخلص: | In this study, presurgical gamma camera imaging and an intraoperative gamma detection probe were used in 12 consecutive patients 6 to 22 days after infusion with indium 111-labeled anticarcinoembryonic antigen monoclonal antibody (111In-MoAb). In three of 11 patients who underwent laparotomy, clinical management was affected by the probe findings: localization of occult retroperitoneal disease, identification of an occult cecal lesion, and localization of residual disease at a site of local recurrence. Of all intra-abdominal lesions seen using any method, the probe identified 18 (86%) of 21, compared with 14 (67%) of 21 with the 111In-MoAb scan, 10 (48%) of 21 by computed tomographic scan, and 16 (76%) of 21 after surgical exploration. Uptake of 111In-MoAb in the portal (n = 3) and mediastinal (n = 3) lymph nodes was not associated with histologic findings of malignant neoplasms. For all pathologically confirmed extrahepatic and nonportal sites of cancer, the probe localized nine of nine, compared with five of nine by 111In-MoAb scan, two of nine by computed tomographic scan, and six of nine by surgical exploration. Important clinical uses of the intraoperative probe included occult lesion identification, localization of areas with 111In uptake shown with MoAb scanning, and verification of complete resection of areas with 111In-MoAb uptake. |
| معلومات مُعتمدة: | CA 09477 United States CA NCI NIH HHS; CA 33572 United States CA NCI NIH HHS; CA 43904 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Carcinoembryonic Antigen) 0 (Indium Radioisotopes) |
| تواريخ الأحداث: | Date Created: 19911101 Date Completed: 19920116 Latest Revision: 20190704 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1001/archsurg.1991.01410350092013 |
| PMID: | 1747053 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0004-0010 |
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| DOI: | 10.1001/archsurg.1991.01410350092013 |