دورية أكاديمية
Predictors of low response to mild ovarian stimulation initiated on cycle day 5 for IVF.
| العنوان: | Predictors of low response to mild ovarian stimulation initiated on cycle day 5 for IVF. |
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| المؤلفون: | Verberg MF; Department of Reproductive Medicine and Gynaecology, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CS Utrecht, The Netherlands. m.f.g.verberg@umcutrecht.nl, Eijkemans MJ, Macklon NS, Heijnen EM, Fauser BC, Broekmans FJ |
| المصدر: | Human reproduction (Oxford, England) [Hum Reprod] 2007 Jul; Vol. 22 (7), pp. 1919-24. Date of Electronic Publication: 2007 May 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8701199 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0268-1161 (Print) Linking ISSN: 02681161 NLM ISO Abbreviation: Hum Reprod Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, UK : Oxford University Press Original Publication: Oxford ; Washington, DC : Published for the European Society of Human Reproduction and Embryology by IRL Press, [c1986- |
| مواضيع طبية MeSH: | Fertilization in Vitro/*methods , Ovulation Induction/*methods, Adult ; Female ; Follicle Stimulating Hormone/therapeutic use ; Humans ; Infertility, Female/therapy ; Infertility, Male/therapy ; Male ; Ovary/metabolism ; Ovary/pathology ; Pregnancy ; Pregnancy Rate ; Prognosis ; Sensitivity and Specificity ; Treatment Outcome |
| مستخلص: | Background: Milder stimulation protocols are being developed to minimize adverse effects of ovarian stimulation in in vitro fertilization (IVF) programs. A drawback is the possibility of an increased rate of insufficient ovarian response. This study aimed to develop a prognostic model for the prediction of cycle cancellation due to insufficient response to mild stimulation. Methods: A total of 174 IVF patients aged<38 years and with a body mass index (BMI)<28 Kg/m2 were treated with mild ovarian stimulation using a fixed daily dose (150 IU) of recombinant follicle-stimulating hormone (rFSH) from cycle day 5 and GnRH antagonist from the late follicular phase. In women with mono- or bifollicular growth (17%), the cycle was cancelled and the treatment was adjusted in a second treatment cycle by starting rFSH on cycle day 2. Results: In a multivariable logistic regression analysis, duration of infertility, menstrual cycle length, secondary infertility and BMI were included in the prediction model. The area under the receiver-operating characteristics curve of the model was 0.69. A probability cut-off for cancellation of 0.3 yielded an expected sensitivity of 33% and specificity of 92%. Analysis of ovarian response in the subsequent treatment cycle showed an improved ovarian response and a significant reduction in the cancellation rate. Conclusions: With the presented model, it is possible to identify patients at risk for cycle cancellation, during mild ovarian stimulation, due to insufficient response. The contributing factors of the model suggest that ovarian aging and BMI are related to insufficient response to mild stimulation. |
| المشرفين على المادة: | 9002-68-0 (Follicle Stimulating Hormone) |
| تواريخ الأحداث: | Date Created: 20070509 Date Completed: 20070926 Latest Revision: 20070621 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1093/humrep/dem089 |
| PMID: | 17485438 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0268-1161 |
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| DOI: | 10.1093/humrep/dem089 |