دورية أكاديمية
Dopamine levels after repetitive transcranial magnetic stimulation of motor cortex in patients with Parkinson's disease: preliminary results.
| العنوان: | Dopamine levels after repetitive transcranial magnetic stimulation of motor cortex in patients with Parkinson's disease: preliminary results. |
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| المؤلفون: | Khedr EM; Department of Neurology, Assiut University Hospital, Assiut, Egypt. emankhedr99@yahoo.com, Rothwell JC, Shawky OA, Ahmed MA, Foly N, Hamdy A |
| المصدر: | Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2007 May 15; Vol. 22 (7), pp. 1046-50. |
| نوع المنشور: | Clinical Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8610688 Publication Model: Print Cited Medium: Print ISSN: 0885-3185 (Print) Linking ISSN: 08853185 NLM ISO Abbreviation: Mov Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001->: New York, NY : Wiley-Liss Original Publication: [New York, N.Y.] : Raven Press, [c1986- |
| مواضيع طبية MeSH: | Transcranial Magnetic Stimulation*, Dopamine/*metabolism , Motor Cortex/*metabolism , Parkinson Disease/*pathology, Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Parkinson Disease/metabolism |
| مستخلص: | Background: Repeated session of repetitive transcranial magnetic stimulation (rTMS) over motor cortex have been reported to produce significant improvement of motor performance in patients with parkinson's disease (PD). In addition, it is known that a single session of rTMS over motor cortex transiently increases DA in striatum. Here, we test whether repeated sessions of rTMS increase serum dopamine in PD patients and whether this correlates with changes in clinical rating scales. Material and Methods: Twenty untreated PD patients with moderate to severe symptoms (Hoehn & Yahr state III-V 1967) were assessed on the Unified Parkinson's Disease Rating Scale (UPDRS), and with an enzyme immunoassay for quantitative determination of plasma dopamine before and after six daily sessions of 25 Hz rTMS with 3,000 stimuli over the right and left hand and leg motor cortex. Results: There was significant improvement in UPDRS compared with the baseline. Serum dopamine level also was significantly elevated over the same interval. There was a significant correlation between UPDRS and serum dopamine level before and after treatment. Conclusion: Improved motor performance in PD after repeated session of rTMS may be related to an elevation of serum dopamine concentration. ((c) 2007 Movement Disorder Society.) |
| المشرفين على المادة: | VTD58H1Z2X (Dopamine) |
| تواريخ الأحداث: | Date Created: 20070619 Date Completed: 20070803 Latest Revision: 20220318 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/mds.21460 |
| PMID: | 17575584 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0885-3185 |
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| DOI: | 10.1002/mds.21460 |