دورية أكاديمية
Cumulative pregnancy rates after a maximum of nine cycles of modified natural cycle IVF and analysis of patient drop-out: a cohort study.
| العنوان: | Cumulative pregnancy rates after a maximum of nine cycles of modified natural cycle IVF and analysis of patient drop-out: a cohort study. |
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| المؤلفون: | Pelinck MJ; Section of Reproductive Medicine, Department of Obstetrics and Gynaecology, University Medical Center Groningen, Groningen, The Netherlands. pelinck@hotmail.com, Vogel NE, Arts EG, Simons AH, Heineman MJ, Hoek A |
| المصدر: | Human reproduction (Oxford, England) [Hum Reprod] 2007 Sep; Vol. 22 (9), pp. 2463-70. Date of Electronic Publication: 2007 Jun 23. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8701199 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0268-1161 (Print) Linking ISSN: 02681161 NLM ISO Abbreviation: Hum Reprod Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, UK : Oxford University Press Original Publication: Oxford ; Washington, DC : Published for the European Society of Human Reproduction and Embryology by IRL Press, [c1986- |
| مواضيع طبية MeSH: | Patient Dropouts* , Pregnancy Rate*, Fertilization in Vitro/*methods , Infertility, Female/*therapy, Adult ; Cohort Studies ; Embryo Transfer ; Female ; Humans ; Netherlands ; Pregnancy |
| مستخلص: | Background: In modified natural cycle IVF (MNV-IVF), treatment is aimed at using the one follicle that spontaneously develops to dominance, using a GnRH antagonist together with gonadotrophins in the late follicular phase only. Methods: In this single-centre cohort study, nine cycles of MNV-IVF were offered to 268 patients. Cumulative pregnancy rates (CPRs) were calculated and drop-out was analysed. The present study is an extension of earlier studies in which three cycles of MNV-IVF were offered to the same patients. Results: A total of 256 patients completed 1048 cycles (4.1 per patient). Embryo transfer rate was 36.5% per started cycle. Ongoing pregnancy rate was 7.9% per started cycle and 20.7% per embryo transfer. Including treatment-independent pregnancies, the observed CPR after up to nine cycles was 44.4% (95% confidence interval 38.3-50.5) per patient. Pregnancy rates per started cycle did not decline in higher cycle numbers (overall 9.9%). Drop-out rates were high (overall 47.8%). We found that cancellation of oocyte retrieval, fertilization failure and failure to reach embryo transfer are repeating phenomena in subsequent cycles and furthermore that these events predispose for drop-out. Conclusions: CPR after nine cycles of MNV-IVF in this study was 44.4%. Pregnancy rate per cycle did not decline in higher cycle numbers, possibly due to selective drop-out of poor prognosis patients. Due to the low-risk and patient-friendly nature of the MNC protocol, it seems a feasible treatment option for patients requiring IVF. |
| تواريخ الأحداث: | Date Created: 20070626 Date Completed: 20071121 Latest Revision: 20070820 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/humrep/dem164 |
| PMID: | 17586833 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0268-1161 |
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| DOI: | 10.1093/humrep/dem164 |