دورية أكاديمية
Acceleration of luteinizing hormone pulse frequency in adolescent girls with a history of central precocious puberty with versus without hyperandrogenism.
| العنوان: | Acceleration of luteinizing hormone pulse frequency in adolescent girls with a history of central precocious puberty with versus without hyperandrogenism. |
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| المؤلفون: | Escobar ME; Centro de Investigaciones Endocrinológicas (CEDIE), División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina. meugeniaescobar@cedie.org.ar, Ropelato MG, Ballerini MG, Gryngarten MG, Rudaz MC, Veldhuis JD, Barontini M |
| المصدر: | Hormone research [Horm Res] 2007; Vol. 68 (6), pp. 278-85. Date of Electronic Publication: 2007 Jun 20. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0366126 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1423-0046 (Electronic) Linking ISSN: 03010163 NLM ISO Abbreviation: Horm Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, New York, Karger. |
| مواضيع طبية MeSH: | Hyperandrogenism/*complications , Hyperandrogenism/*metabolism , Luteinizing Hormone/*blood , Puberty, Precocious/*complications , Puberty, Precocious/*metabolism, Adolescent ; Androstenedione/blood ; Estrone/blood ; Female ; Fluoroimmunoassay ; Follicle Stimulating Hormone/blood ; Humans ; Luteinizing Hormone/metabolism ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/metabolism ; Testosterone/blood |
| مستخلص: | Unlabelled: Some adolescents with a history of idiopathic central precocious puberty (ICPP) develop hyperandrogenism. Hypothesis: Luteinizing hormone (LH) hypersecretion could be a common mechanism underlying ICPP and polycystic ovary syndrome. Aim: To explore the GnRH-LH axis in those patients. Design: To compare overnight LH secretion in 7 healthy adolescents (CG) with that in patients with prior ICPP [5 with (CPPA) and 7 without (CPPB) hyperandrogenism]. To analyze daytime LH secretion in those patients. Methods: LH secretion was quantified by immunofluorometry and deconvolution analysis. Results: Nighttime mean LH (international units/liter) was higher in CPPA (6.9 +/- 1.5) than in CPPB (3.2 +/- 0.4, p < 0.05) and CG (2.9 +/- 0.4, p < 0.01). Deconvolution analysis revealed a greater nighttime LH frequency (pulses/hour) both in CPPA (0.91 +/- 0.06, p < 0.01) and CPPB (0.74 +/- 0.02, p < 0.05) than in CG (0.45 +/- 0.07). CPPA patients maintained a higher frequency than CPPB. Pulsatile LH production was greater in CPPA than in CG (50 +/- 12 vs. 18 +/- 3 IU/l/day, p < 0.01). Daytime mass of LH released per burst and pulsatile production rate were significantly greater in CPPA than in CPPB patients. Conclusions: Hyperandrogenic adolescents with prior ICPP show increased pulsatile LH secretion. Augmentation of LH pulsatility may predispose to or cause hyperandrogenism in some adolescents with a history of precocious puberty. ((c) 2007 S. Karger AG, Basel.) |
| التعليقات: | Comment in: Horm Res. 2007;68(6):286-7. (PMID: 17587858) |
| معلومات مُعتمدة: | M01 RR000585 United States RR NCRR NIH HHS; M01 RR00585 United States RR NCRR NIH HHS |
| المشرفين على المادة: | 2DI9HA706A (Estrone) 3XMK78S47O (Testosterone) 409J2J96VR (Androstenedione) 9002-67-9 (Luteinizing Hormone) 9002-68-0 (Follicle Stimulating Hormone) |
| تواريخ الأحداث: | Date Created: 20070626 Date Completed: 20071213 Latest Revision: 20181201 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1159/000104177 |
| PMID: | 17587857 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1423-0046 |
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| DOI: | 10.1159/000104177 |