دورية أكاديمية
Treatment of kala-azar in southern Sudan using a 17-day regimen of sodium stibogluconate combined with paromomycin: a retrospective comparison with 30-day sodium stibogluconate monotherapy.
| العنوان: | Treatment of kala-azar in southern Sudan using a 17-day regimen of sodium stibogluconate combined with paromomycin: a retrospective comparison with 30-day sodium stibogluconate monotherapy. |
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| المؤلفون: | Melaku Y; Médecins sans Frontières-Holland, Amsterdam, The Netherlands., Collin SM, Keus K, Gatluak F, Ritmeijer K, Davidson RN |
| المصدر: | The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2007 Jul; Vol. 77 (1), pp. 89-94. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Print Cited Medium: Print ISSN: 0002-9637 (Print) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene Original Publication: Baltimore. |
| مواضيع طبية MeSH: | Antimony Sodium Gluconate/*administration & dosage , Antiprotozoal Agents/*administration & dosage , Leishmaniasis, Visceral/*epidemiology , Leishmaniasis, Visceral/*prevention & control , Paromomycin/*administration & dosage, Adolescent ; Child ; Child, Preschool ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Humans ; Infant ; Infant, Newborn ; Leishmaniasis, Visceral/etiology ; Leishmaniasis, Visceral/mortality ; Male ; Medical Records ; Retrospective Studies ; Sudan/epidemiology ; Treatment Outcome |
| مستخلص: | Médecins sans Frontières-Holland has treated > 67,000 patients with kala-azar (KA) in southern Sudan since 1989. In 2002, we replaced the standard regimen of 30 days of daily sodium stibogluconate (SSG) with a 17-day regimen of daily SSG combined with paromomycin (PM). We analyzed data for 4,263 primary KA patients treated between 2002 and 2005 in southern Sudan to determine the relative efficacy of the combination therapy regimen (PM/SSG). The initial cure rate among patients treated with PM/SSG was 97.0% compared with 92.4% among patients treated with SSG monotherapy. Relative efficacy of PM/SSG compared with SSG increased over the study period: odds of death in the PM/SSG group were 44% lower (odds ratio [OR] = 0.56, 95% confidence interval [CI] = 0.37-0.84) in 2002, 78% lower (OR = 0.22, 95% CI = 0.10-0.50) in 2003, and 86% lower (OR = 0.14, 95% CI = 0.07-0.27) in 2004-2005. In remote field settings, 17 days of SSG combined with PM gives better survival and initial cure rates than 30 days of SSG monotherapy. |
| المشرفين على المادة: | 0 (Antiprotozoal Agents) 61JJC8N5ZK (Paromomycin) V083S0159D (Antimony Sodium Gluconate) |
| تواريخ الأحداث: | Date Created: 20070711 Date Completed: 20070920 Latest Revision: 20131121 |
| رمز التحديث: | 20240628 |
| PMID: | 17620635 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0002-9637 |
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