دورية أكاديمية
Haematogenous dissemination of tuberculous lymphadenitis.
| العنوان: | Haematogenous dissemination of tuberculous lymphadenitis. |
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| المؤلفون: | Sharafeldin GS; National Health Laboratory, Federal Ministry of Health, Khartoum, Sudan., Khalil EA, El Hag IA, Elsiddig KE, Elsafi ME, Aijafari AS, Elnour AA, Hussein AM, Elkhidir IM, El-Hassan AM |
| المصدر: | East African medical journal [East Afr Med J] 2007 Jan; Vol. 84 (1), pp. 3-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medical Association of East Africa Country of Publication: Kenya NLM ID: 0372766 Publication Model: Print Cited Medium: Print ISSN: 0012-835X (Print) Linking ISSN: 0012835X NLM ISO Abbreviation: East Afr Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Nairobi Medical Association of East Africa |
| مواضيع طبية MeSH: | Mycobacterium tuberculosis/*isolation & purification , Tuberculosis, Lymph Node/*blood, Adult ; Biopsy, Fine-Needle ; Confidence Intervals ; DNA, Bacterial/blood ; Female ; Humans ; Lymph Nodes/microbiology ; Lymph Nodes/pathology ; Male ; Middle Aged ; Mycobacterium tuberculosis/genetics ; Odds Ratio ; Polymerase Chain Reaction ; Prospective Studies ; Sudan ; Tuberculosis, Lymph Node/pathology |
| مستخلص: | Objective: To determine whether Mycobacterium tuberculosis infection spreads through the blood to different lymph-node groups in patients with tuberculous lymphadenitis. Design: Prospective analytical study. Setting: The patients were recruited, managed and followed at the lymphodenopathy clinic, Central Police Hospital, Burr, Khartoum, Sudan. Subjects: Fifty two sequential patients were enrolled. Thirty patients with FNAC diagnosis of tuberculous lymphadenitis and positive PCR for M. tuberculosis complex had a mean age of 26.9 +/- 11.2 years and similar male, female affection. Nine patients with FNAC tuberculous lymphadenitis, but negative PCR had a slightly higher mean age (32.6 +/- 18.2 years) with similar male: female proportions. Patients with reactive lymphadenopathy (9/52) were older than patients with tuberculous lymphadenitis with a mean age of 45 +/- 24.6 years. Results: None of the patients were positive for HIV or had clinical or radiological evidence of pulmonary tuberculosis. M. tuberculosis DNA was detected in the blood samples of 30/39 (77%) patients with tuberculous lymphadenitis, but in none of the cases with reactive or malignant lymphadenopathy. The presence of M. tuberculosis DNA correlated strongly to multiple lymph-node involvement [OR (odds ratio) = 96.7, 95% confidence interval (CI) 9.0 - 1,039] and to caseating-granulomatous and predominantly necrotic cytomorphological categories [OR = 70, 95% confidence interval (CI) 7.0 - 703]. Conclusion: M. tuberculosis most probably disseminates through the blood from one node group to the other in patients with tuberculous lymphadenitis. |
| المشرفين على المادة: | 0 (DNA, Bacterial) |
| تواريخ الأحداث: | Date Created: 20070719 Date Completed: 20070831 Latest Revision: 20190923 |
| رمز التحديث: | 20221213 |
| DOI: | 10.4314/eamj.v84i1.9484 |
| PMID: | 17633578 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0012-835X |
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| DOI: | 10.4314/eamj.v84i1.9484 |