دورية أكاديمية
Vasopressin response to haemorrhage in rats: effect of hypoxia and water restriction.
| العنوان: | Vasopressin response to haemorrhage in rats: effect of hypoxia and water restriction. |
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| المؤلفون: | Raff H; Endocrine Research Laboratory, St Luke's Medical Center, Milwaukee, Wisconsin 53215., Rossing MH, Doepker SK, Griffen SC, Jankowski BM |
| المصدر: | Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 1991 Oct; Vol. 18 (10), pp. 725-9. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: Australia NLM ID: 0425076 Publication Model: Print Cited Medium: Print ISSN: 0305-1870 (Print) Linking ISSN: 03051870 NLM ISO Abbreviation: Clin Exp Pharmacol Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, England : Wiley-Blackwell Original Publication: Oxford, Blackwell Scientific Publications. |
| مواضيع طبية MeSH: | Hemorrhage/*physiopathology , Hypoxia/*physiopathology , Vasopressins/*pharmacology , Water Deprivation/*physiology, Animals ; Blood Pressure/physiology ; Hemorrhage/blood ; Hypoxia/blood ; Male ; Rats ; Rats, Inbred Strains ; Vasopressins/blood ; Vasopressins/metabolism |
| مستخلص: | 1. The aim of the present study was to determine the effect of water restriction and/or hypoxia on the vasopressin response to haemorrhage in conscious rats. 2. Male, Long-Evans rats (n = 39) were prepared with chronically indwelling femoral artery and vein catheters and exposed to 24 h of one of the following: normoxia with ad lib drinking water (N + W); normoxia with water restriction (N - W); hypoxia with ad lib drinking water (H + W); and hypoxia with water restriction (H - W). At the end of 24 h, a 15 mL/kg arterial haemorrhage was performed. 3. Water restricted rats had elevated pre-haemorrhage vasopressin levels. Haemorrhage induced an increase in vasopressin in all groups. Water restriction (N - W) or hypoxia (H + W) each augmented the vasopressin response to haemorrhage. However, the combination of hypoxia and water restriction (H - W) failed to augment the vasopressin response to haemorrhage as compared to normoxic, water replete (N + W) rats. 4. Hypoxia or water restriction per se augment the vasopressin response to haemorrhage. This augmented vasopressin response to haemorrhage is not maintained when hypoxia and water restriction are combined. |
| معلومات مُعتمدة: | GM07892 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 11000-17-2 (Vasopressins) |
| تواريخ الأحداث: | Date Created: 19911001 Date Completed: 19920218 Latest Revision: 20190824 |
| رمز التحديث: | 20221208 |
| DOI: | 10.1111/j.1440-1681.1991.tb01387.x |
| PMID: | 1764817 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0305-1870 |
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| DOI: | 10.1111/j.1440-1681.1991.tb01387.x |