دورية أكاديمية
Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women.
| العنوان: | Estrogen plus progestin use, microsatellite instability, and the risk of colorectal cancer in women. |
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| المؤلفون: | Newcomb PA; Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, Washington 98109, USA. pnewcomb@fhcrc.org, Zheng Y, Chia VM, Morimoto LM, Doria-Rose VP, Templeton A, Thibodeau SN, Potter JD |
| المصدر: | Cancer research [Cancer Res] 2007 Aug 01; Vol. 67 (15), pp. 7534-9. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Print ISSN: 0008-5472 (Print) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Baltimore, Md. : American Association for Cancer Research Original Publication: Chicago [etc.] |
| مواضيع طبية MeSH: | Colorectal Neoplasms/*genetics , Estrogens/*pharmacology , Microsatellite Repeats/*genetics , Progestins/*pharmacology, Aged ; Case-Control Studies ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/metabolism ; Contraceptives, Oral, Hormonal/pharmacology ; Drug Therapy, Combination ; Estrogen Replacement Therapy ; Female ; Humans ; Middle Aged ; Obesity/genetics ; Obesity/metabolism ; Postmenopause/metabolism ; Risk Assessment |
| مستخلص: | Current users of postmenopausal hormones (PMH) have approximately 30% to 40% lower risk of colorectal cancer (CRC), although associations with specific types of hormones have been inconsistent. Further, it is not clear whether some tumor types have a different risk. We conducted a case-control study to examine the relationship between PMH and CRC. Cases (n = 1,004), ages 50 to 74 years, were identified from the Surveillance Epidemiology and End Results registry in Washington from 1998 to 2002; controls (n = 1,062) were randomly selected from population lists. Case tissue samples were obtained for microsatellite instability (MSI) analyses. Interviews collected risk-factor data for CRC, including detailed information on PMH. Multivariable logistic regression models estimated odds ratios (OR) and 95% confidence intervals (95% CI). Current use of any PMH was associated with a 20% reduction in CRC risk (95% CI 0.6-0.9). This reduction in risk was limited to women who had taken estrogen plus progestin (EP) preparations only (OR = 0.6, 95% CI 0.5-0.9); there was no association with estrogen-only (E alone) use (OR = 0.9, 95% CI 0.7-1.1). For women with MSI-low or MSI-stable tumors, there was a statistically significant 40% reduction in CRC risk associated with EP use (95% CI 0.4-0.9); there was no clear association with MSI-high tumors. EP use was associated with a decreased risk of CRC; however, there seemed to be no association with E alone data that are consistent with the recent Women's Health Initiative findings. Progestin may enhance the estrogenic effect of conjugated estrogen so the combination may be more biologically active in the colon than E alone. |
| معلومات مُعتمدة: | U01 CA074794 United States CA NCI NIH HHS; R01CA76366 United States CA NCI NIH HHS; U01CA74794 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Contraceptives, Oral, Hormonal) 0 (Estrogens) 0 (Progestins) |
| تواريخ الأحداث: | Date Created: 20070803 Date Completed: 20070911 Latest Revision: 20161019 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1158/0008-5472.CAN-06-4275 |
| PMID: | 17671225 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0008-5472 |
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| DOI: | 10.1158/0008-5472.CAN-06-4275 |