دورية أكاديمية
Experimental severe Pseudomonas aeruginosa pneumonia and antibiotic therapy in piglets receiving mechanical ventilation.
| العنوان: | Experimental severe Pseudomonas aeruginosa pneumonia and antibiotic therapy in piglets receiving mechanical ventilation. |
|---|---|
| المؤلفون: | Luna CM; Acevedo 1070, Banfield (1828), Buenos Aires, Argentina. cymluna@advancedsl.com.ar, Baquero S, Gando S, Patrón JR, Morato JG, Sibila O, Absi R, Famiglietti A, Vay CA, Von Stecher F, Agustí C, Torres A |
| المصدر: | Chest [Chest] 2007 Aug; Vol. 132 (2), pp. 523-31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0231335 Publication Model: Print Cited Medium: Print ISSN: 0012-3692 (Print) Linking ISSN: 00123692 NLM ISO Abbreviation: Chest Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York : Elsevier Original Publication: Chicago : American College of Chest Physicians |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*therapeutic use , Pneumonia, Bacterial/*drug therapy , Pseudomonas Infections/*drug therapy , Pseudomonas aeruginosa/*isolation & purification , Respiration, Artificial/*adverse effects, Animals ; Bronchoalveolar Lavage Fluid/chemistry ; Bronchoalveolar Lavage Fluid/microbiology ; Bronchoscopy ; C-Reactive Protein/metabolism ; Disease Models, Animal ; Follow-Up Studies ; Interleukin-6/metabolism ; Nephelometry and Turbidimetry ; Pneumonia, Bacterial/etiology ; Pneumonia, Bacterial/pathology ; Pseudomonas Infections/etiology ; Pseudomonas Infections/pathology ; Risk Factors ; Severity of Illness Index ; Swine ; Treatment Outcome ; Tumor Necrosis Factor-alpha/metabolism |
| مستخلص: | Background: Little is known about the general and local consequences of severe pneumonia under mechanical ventilation (SPMV) and how these are resolved with antibiotic therapy (ABT). Objectives: To investigate the physiologic, biological, microbiological, and pathologic changes produced by experimental SPMV in a porcine model, and to evaluate the effect of ABT. Methods: Pseudomonas aeruginosa was inoculated in 12 large white-Landrace piglets receiving mechanical that were killed after 72 h if death did not occur before. Vital signs, serum and BAL cytokines, serum C-reactive protein (CRP), and graded postmortem lung pathology and cultures (blood and quantitative BAL and lung) were evaluated. Six piglets received inappropriate ABT (no ABT or ceftriaxone), and six piglets received appropriate ABT (ciprofloxacin). Measurements and Main Results: Pathologic and microbiological evidence of infection were present in all the animals in both groups. SPMV produced significant oxygenation and lung compliance worsening, increased serum CRP, and reduced BAL fluid tumor necrosis factor (TNF)-alpha. Arterial thrombosis in lung pathology was associated with higher temperature, hypoxemia and low lung compliance, higher initial serum CRP and TNF-alpha concentrations, and increased serum interleukin (IL)-6 and BAL IL-6 and TNF-alpha. Reduced ABT reduced body temperature and culture positivity. Conclusions: This model resembles VAP and has been used for studying pulmonary infection and inflammation related to mechanical ventilation. ABT reduced fever and bacterial burden in SPMV but had no effect on cytokine or CRP concentrations, oxygenation, or lung mechanics. Pulmonary artery thrombosis was associated with worse response to infection. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Interleukin-6) 0 (Tumor Necrosis Factor-alpha) 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20070819 Date Completed: 20071002 Latest Revision: 20140729 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1378/chest.07-0185 |
| PMID: | 17699131 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0012-3692 |
|---|---|
| DOI: | 10.1378/chest.07-0185 |