دورية أكاديمية
Effect of oxytocics on the blood pressure of normotensive Nigerian parturients.
| العنوان: | Effect of oxytocics on the blood pressure of normotensive Nigerian parturients. |
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| المؤلفون: | Jago AA; Department of Obstetrics & Gynaecology, Federal Medical Centre, Makurdi, Nigeria., Ezechi OC, Achinge GI, Okunlola MA |
| المصدر: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2007 Sep; Vol. 20 (9), pp. 703-5. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print Cited Medium: Print ISSN: 1476-7058 (Print) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Boca Raton : Parthenon Pub. Group, c2002- |
| مواضيع طبية MeSH: | Blood Pressure/*drug effects , Ergonovine/*therapeutic use , Oxytocics/*pharmacology , Oxytocics/*therapeutic use , Oxytocin/*therapeutic use , Parturition/*drug effects , Postpartum Hemorrhage/*prevention & control, Double-Blind Method ; Ergonovine/pharmacology ; Female ; Humans ; Labor Stage, Third/drug effects ; Nigeria ; Oxytocin/pharmacology ; Pregnancy |
| مستخلص: | Background: The single most common direct obstetric disorder accounting for 25% of all maternal deaths globally is severe hemorrhage, generally occurring postpartum. Nearly all these deaths occur in the developing world. The role of oxytocic drugs in the management of the third stage of labor as a strategy to reduce maternal mortality has been emphasized. However, the adverse effects of these oxytocic agents, in particular ergometrine, have not been properly evaluated in our environment. Objectives: To evaluate the effect of ergometrine and oxytocin on the cardiovascular system when used for active management of the third stage of labor. Study Design: A double-blind, randomized controlled study was carried out at the Federal Medical Centre, Makurdi over 24 months. Five hundred and ten patients were randomized to treatment with either 0.5 mg of intramuscular ergometrine or 10 IU of intravenous oxytocin, respectively, as single injections. Their effects on the cardiovascular system were observed using blood pressure as a marker. Results: Ergometrine unlike oxytocin was observed to cause a significant rise in blood pressure, and this effect was most marked in the first 24 hours of the puerperium. Conclusions: These results suggest that ergometrine may be safe in normotensive parturients but hazardous in hypertensive parturients in whom oxytocin would be a safer option. |
| المشرفين على المادة: | 0 (Oxytocics) 50-56-6 (Oxytocin) WH41D8433D (Ergonovine) |
| تواريخ الأحداث: | Date Created: 20070819 Date Completed: 20080104 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/14767050701500406 |
| PMID: | 17701671 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1476-7058 |
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| DOI: | 10.1080/14767050701500406 |