دورية أكاديمية
Simultaneous determination of nontricyclic antidepressants in human plasma by solid-phase microextraction and liquid chromatography (SPME-LC).
| العنوان: | Simultaneous determination of nontricyclic antidepressants in human plasma by solid-phase microextraction and liquid chromatography (SPME-LC). |
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| المؤلفون: | Gonçalves Silva BJ; Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-901, SP, Brasil., Costa Queiroz RH, Costa Queiroz ME |
| المصدر: | Journal of analytical toxicology [J Anal Toxicol] 2007 Jul-Aug; Vol. 31 (6), pp. 313-20. |
| نوع المنشور: | Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7705085 Publication Model: Print Cited Medium: Print ISSN: 0146-4760 (Print) Linking ISSN: 01464760 NLM ISO Abbreviation: J Anal Toxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2012- : Oxford : Oxford University Press Original Publication: 1977-<2011>: Niles, Ill., Preston Publications. |
| مواضيع طبية MeSH: | Antidepressive Agents/*blood , Citalopram/*blood , Fluoxetine/*blood , Mianserin/*analogs & derivatives , Paroxetine/*blood , Sertraline/*blood, Aged ; Antidepressive Agents/pharmacokinetics ; Chromatography, Liquid ; Citalopram/pharmacokinetics ; Fluoxetine/pharmacokinetics ; Humans ; Mianserin/blood ; Mianserin/pharmacokinetics ; Mirtazapine ; Paroxetine/pharmacokinetics ; Reproducibility of Results ; Sertraline/pharmacokinetics ; Solid Phase Microextraction |
| مستخلص: | A sensitive, selective, and reproducible solid-phase microextraction and liquid chromatographic (SPME-LC) method for simultaneous determination of mirtazapine, citalopram, paroxetine, fluoxetine, and sertraline in human plasma was developed, validated, and further applied to analyze plasma samples obtained from patients with depression. Important factors in the optimization of SPME efficiency are discussed, including the fiber coating, extraction time, pH, ionic strength, influence of plasma proteins, and desorption conditions. The limit of quantitation of the nontricyclic antidepressants in plasma varied from 25 to 50 ng/mL with a coefficient of variation lower than 5%. The response of the SPME-LC method for most of the drugs was linear over a dynamic range of 50 to 500 ng/mL, with all of them having correlation coefficients greater than 0.9970. The performance of the SPME-LC method allowed the nontricyclic antidepressants analyses in therapeutic levels. |
| المشرفين على المادة: | 0 (Antidepressive Agents) 01K63SUP8D (Fluoxetine) 0DHU5B8D6V (Citalopram) 250PJI13LM (Mianserin) 41VRH5220H (Paroxetine) A051Q2099Q (Mirtazapine) QUC7NX6WMB (Sertraline) |
| تواريخ الأحداث: | Date Created: 20070830 Date Completed: 20070926 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1093/jat/31.6.313 |
| PMID: | 17725876 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0146-4760 |
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| DOI: | 10.1093/jat/31.6.313 |