دورية أكاديمية
Differences in peripheral blood lymphocyte phenotypes between Helicobacter pylori-positive children and adults with duodenal ulcer.
| العنوان: | Differences in peripheral blood lymphocyte phenotypes between Helicobacter pylori-positive children and adults with duodenal ulcer. |
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| المؤلفون: | Figueiredo Soares T; Laboratory of Research in Bacteriology, Faculdade de Medicina/UFMG, Belo Horizonte, Brazil., Aguiar Rocha G, Camargos Rocha AM, Corrêa-Oliveira R, Martins-Filho OA, Teles Carvalho AS, Souto Bittencourt PF, Afonso Oliveira C, Ferreira Nogueira AM, Alvares Cabral MM, Caetano Faria AM, Queiroz DM |
| المصدر: | Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2007 Nov; Vol. 13 (11), pp. 1083-8. Date of Electronic Publication: 2007 Aug 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1198-743X (Print) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : London : Elsevier Original Publication: Paris : Decker Europe, c1995- |
| مواضيع طبية MeSH: | CD4-Positive T-Lymphocytes/*immunology , CD8-Positive T-Lymphocytes/*immunology , Duodenal Ulcer/*immunology , Helicobacter Infections/*immunology , Helicobacter pylori/*immunology, Adolescent ; Adult ; Age Factors ; Aged ; B-Lymphocytes/immunology ; Child ; Duodenal Ulcer/blood ; Female ; HLA-DR Antigens/immunology ; Helicobacter Infections/microbiology ; Humans ; Immunophenotyping/methods ; Male ; Middle Aged ; Prospective Studies ; T-Lymphocyte Subsets/immunology |
| مستخلص: | The immunological mechanisms involved in the development of duodenal ulcer, especially in childhood, are unclear. Helicobacter pylori-positive children and adults, with and without duodenal ulcer, were therefore compared with respect to CD4(+) T-cells, and CD8(+) T-cells, B-cells and B1a-cells, as well as cell activation (CD4(+)/HLA-DR(+) and CD8(+)/HLA-DR(+)) and co-stimulatory (CD4(+)/CD28(+) and CD8(+)/CD28(+)) markers, in peripheral blood. Children with and without duodenal ulcer differed significantly. In particular, there was a phenotypic change in CD8(+) T-cells from children with ulcer that involved a 200% increase in the number of CD8(+)/HLA-DR(+) cells/mm(3) and a decrease of 34.2% in the number of CD8(+)/CD28(+) cells/mm(3). This phenotype of chronically activated memory CD8(+) T-cells, which has also been observed in patients with AIDS and tuberculosis, is associated with disease severity and progression. A lower frequency of B1a-cells was also observed in the group of children with ulcer. Conversely, no difference between infected adults with and without ulcer was observed, but the percentage of CD4(+)/HLA-DR(+) cells was lower in adults with ulcer, suggesting that a down-regulated immune response may play a role in the development of duodenal ulcer in adults. Gastric inflammation correlated positively with CD4(+) and chronically activated CD4(+) T-cells in children and adults without duodenal ulcer, respectively. These results suggest that there are differences in the immunophenotyping profile between H. pylori-positive children and adults with duodenal ulcer, indicating the possibility of distinct immune mechanisms in the development of the disease according to age. |
| المشرفين على المادة: | 0 (HLA-DR Antigens) |
| تواريخ الأحداث: | Date Created: 20070831 Date Completed: 20080108 Latest Revision: 20071009 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1469-0691.2007.01814.x |
| PMID: | 17727687 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1198-743X |
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| DOI: | 10.1111/j.1469-0691.2007.01814.x |