دورية أكاديمية
Paracrine role of prostanoids in activation of arterial baroreceptors: an overview.
| العنوان: | Paracrine role of prostanoids in activation of arterial baroreceptors: an overview. |
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| المؤلفون: | Chapleau MW; Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242., Hajduczok G, Abboud FM |
| المصدر: | Clinical and experimental hypertension. Part A, Theory and practice [Clin Exp Hypertens A] 1991; Vol. 13 (5), pp. 817-24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Dekker Country of Publication: United States NLM ID: 8207790 Publication Model: Print Cited Medium: Print ISSN: 0730-0077 (Print) Linking ISSN: 07300077 NLM ISO Abbreviation: Clin Exp Hypertens A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, N.Y. : Dekker, c1982-c1992. |
| مواضيع طبية MeSH: | Arteries/*physiology , Hormones/*physiology , Pressoreceptors/*physiology , Prostaglandins/*physiology, Animals |
| مستخلص: | Baroreceptors located in carotid sinuses and aortic arch are activated with increases in arterial pressure. The increased afferent nerve activity triggers reflex adjustments that buffer the rise in pressure. Mechanical deformation of baroreceptor nerve endings is considered the primary mechanism of receptor activation. Recent studies in our laboratory have demonstrated that prostanoids, most likely released from endothelial cells during stretch, contribute--as paracrine factors--to the activation of baroreceptors. Exposure of the isolated carotid sinus in anesthetized rabbits to prostacyclin (PGI2) or arachidonic acid increases baroreceptor sensitivity whereas inhibition of endogenous formation of prostanoids with indomethacin or aspirin decreases sensitivity. Baroreceptor sensitivity is also decreased after endothelial denudation and restored after adding PGI2 back to the denuded sinus suggesting that endothelium is the source of prostanoids that sensitize baroreceptors. Pathologic states such as chronic hypertension and atherosclerosis are associated with both endothelial cell dysfunction and decreased baroreceptor sensitivity. The endothelial cell dysfunction and impairment of prostanoid formation contribute to the decreased baroreceptor sensitivity in these diseases. |
| Number of References: | 14 |
| معلومات مُعتمدة: | HL 14388 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (Hormones) 0 (Prostaglandins) |
| تواريخ الأحداث: | Date Created: 19910101 Date Completed: 19920302 Latest Revision: 20190918 |
| رمز التحديث: | 20240513 |
| DOI: | 10.3109/10641969109042085 |
| PMID: | 1773513 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 0730-0077 |
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| DOI: | 10.3109/10641969109042085 |