دورية أكاديمية
[EBV reactivation in a patient undergoing chemotherapy for invasive thymoma].
| العنوان: | [EBV reactivation in a patient undergoing chemotherapy for invasive thymoma]. |
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| عنوان ترانسليتريتد: | Riattivazione di EBV in un paziente sottoposto a chemioterapia per metastasi da timoma misto invasivo. |
| المؤلفون: | Giordano S; U.O. Malattie Infettive-ARNAS Civico Palermo, Italy., Pampinella D, Alù M, Agostara B, Romano A |
| المصدر: | Le infezioni in medicina [Infez Med] 2007 Sep; Vol. 15 (3), pp. 195-8. |
| نوع المنشور: | Case Reports; English Abstract; Journal Article |
| اللغة: | Italian |
| بيانات الدورية: | Publisher: Edizioni Internazionali srl Country of Publication: Italy NLM ID: 9613961 Publication Model: Print Cited Medium: Print ISSN: 1124-9390 (Print) Linking ISSN: 11249390 NLM ISO Abbreviation: Infez Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Pavia, Italy : Edizioni Internazionali srl Original Publication: Roma : Elsèv edizioni mediche |
| مواضيع طبية MeSH: | Antineoplastic Agents/*adverse effects , Epstein-Barr Virus Infections/*complications , Parotitis/*virology , Thymoma/*drug therapy , Thymus Neoplasms/*drug therapy, Humans ; Male ; Middle Aged ; Neoplasm Invasiveness ; Thymoma/pathology ; Thymoma/secondary ; Thymus Neoplasms/pathology |
| مستخلص: | Over the last few years evidence has emerged to indicate the involvement of herpes viruses in several infectious complications observed in patients undergoing antiblastic chemotherapy. We present a case of bilateral parotiditis due to EBV reactivation in a patient who had received chemotherapy because of an invasive thymoma. In October 2006, a 53-year-old man with pulmonary and pleural metastases owing to an invasive thymoma, was started on chemotherapy with cisplatin, adriamycin and cyclophosphamide. In January 2007, after consultation with an infectious disease specialist, the patient was admitted to the oncology department because of bilateral swelling of the parotid glands which was most likely of infectious or mycotic origin and attributed to immunosuppression by chemotherapy (the last cycle was completed on 28th December 2006). During his hospital stay, the patient underwent routine blood tests, serological tests (EBV-VCA IgM/IgG: positive/positive, EBV-EBNA IgG: positive), cultural and instrumental tests. Due to the serological results, we decided to search for EBV in blood by using PCR (23,000 copies/100,000 cells). We hypothesize that EBV infection could have caused both thymoma and bilateral parotiditis. Accordingly, a multidisciplinary approach, including consultation with an oncologist, infectious disease and microbiology specialists, is the best way to manage infectious complications in patients with a deficit of cells-mediated immunity. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20071018 Date Completed: 20080219 Latest Revision: 20190816 |
| رمز التحديث: | 20231215 |
| PMID: | 17940405 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1124-9390 |
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