دورية أكاديمية
Antifungal and antioxidant activities of the phytomedicine pipsissewa, Chimaphila umbellata.
| العنوان: | Antifungal and antioxidant activities of the phytomedicine pipsissewa, Chimaphila umbellata. |
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| المؤلفون: | Galván IJ; Chemistry Department, Universidad Autónoma de Aguascalientes, Av. Universidad 940, Ags., CP 20100 México, Mexico., Mir-Rashed N, Jessulat M, Atanya M, Golshani A, Durst T, Petit P, Amiguet VT, Boekhout T, Summerbell R, Cruz I, Arnason JT, Smith ML |
| المصدر: | Phytochemistry [Phytochemistry] 2008 Feb; Vol. 69 (3), pp. 738-46. Date of Electronic Publication: 2007 Oct 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0031-9422 (Print) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : London : Elsevier Original Publication: 1961-2003: Oxford : Pergamon Press. |
| مواضيع طبية MeSH: | Antifungal Agents/*pharmacology , Antioxidants/*pharmacology , Malassezia/*drug effects , Naphthoquinones/*pharmacology , Pyrolaceae/*chemistry , Saccharomyces cerevisiae/*drug effects, Antifungal Agents/chemistry ; Antifungal Agents/isolation & purification ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Biphenyl Compounds/chemistry ; Dose-Response Relationship, Drug ; Hydrazines/chemistry ; Magnetic Resonance Spectroscopy/methods ; Malassezia/classification ; Malassezia/growth & development ; Microbial Sensitivity Tests ; Molecular Structure ; Naphthoquinones/chemistry ; Naphthoquinones/isolation & purification ; Picrates ; Saccharomyces cerevisiae/growth & development ; Structure-Activity Relationship |
| مستخلص: | Bioassay-guided fractionation of Chimaphila umbellata (L.) W. Bart (Pyrolaceae) ethanol extracts led to the identification of 2,7-dimethyl-1,4-naphthoquinone (chimaphilin) as the principal antifungal component. The structure of chimaphilin was confirmed by 1H and 13C NMR spectroscopy. The antifungal activity of chimaphilin was evaluated using the microdilution method with Saccharomyces cerevisiae (0.05mg/mL) and the dandruff-associated fungi Malassezia globosa (0.39mg/mL) and Malassezia restricta (0.55mg/mL). Pronounced antioxidant activity of C. umbellata crude extract was also identified using the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, suggesting this phytomedicine has an antioxidant function in wound healing. A chemical-genetic profile was completed with chimaphilin using approximately 4700 S. cerevisiae gene deletion mutants. Cellular roles of deleted genes in the most susceptible mutants and secondary assays indicate that the targets for chimaphilin include pathways involved in cell wall biogenesis and transcription. |
| المشرفين على المادة: | 0 (Antifungal Agents) 0 (Antioxidants) 0 (Biphenyl Compounds) 0 (Hydrazines) 0 (Naphthoquinones) 0 (Picrates) DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl) U8Z086618U (chimaphilin) |
| تواريخ الأحداث: | Date Created: 20071024 Date Completed: 20080718 Latest Revision: 20161124 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.phytochem.2007.09.007 |
| PMID: | 17950387 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0031-9422 |
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| DOI: | 10.1016/j.phytochem.2007.09.007 |