دورية أكاديمية
Blood-brain barrier disruption in post-traumatic epilepsy.
| العنوان: | Blood-brain barrier disruption in post-traumatic epilepsy. |
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| المؤلفون: | Tomkins O; Department of Physiology, Zlotowski Center for Neuroscience, Ben-Gurion University, 84105 Beer-Sheva, Israel., Shelef I, Kaizerman I, Eliushin A, Afawi Z, Misk A, Gidon M, Cohen A, Zumsteg D, Friedman A |
| المصدر: | Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2008 Jul; Vol. 79 (7), pp. 774-7. Date of Electronic Publication: 2007 Nov 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Publishing Group Country of Publication: England NLM ID: 2985191R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-330X (Electronic) Linking ISSN: 00223050 NLM ISO Abbreviation: J Neurol Neurosurg Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : BMJ Publishing Group Original Publication: London : British Medical Association |
| مواضيع طبية MeSH: | Blood-Brain Barrier/*metabolism , Brain Injuries/*complications , Brain Injuries/*metabolism , Capillary Permeability/*physiology , Epilepsy/*etiology , Epilepsy/*metabolism, Adolescent ; Adult ; Blood-Brain Barrier/pathology ; Brain Injuries/pathology ; Case-Control Studies ; Cohort Studies ; Electroencephalography ; Epilepsy/pathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged |
| مستخلص: | Background: Traumatic brain injury (TBI) is an important cause of focal epilepsy. Animal experiments indicate that disruption of the blood-brain barrier (BBB) plays a critical role in the pathogenesis of post-traumatic epilepsy (PTE). Objective: To investigate the frequency, extent and functional correlates of increased BBB permeability in patient with PTE. Methods: 32 head trauma patients were included in the study, with 17 suffering from PTE. Patients underwent brain MRI (bMRI) and were evaluated for BBB disruption, using a novel semi-quantitative technique. Cortical dysfunction was measured using electroencephalography (EEG), and localised using standardised low-resolution brain electromagnetic tomography (sLORETA). Results: Spectral EEG analyses revealed significant slowing in patients with TBI, with no significant differences between patients with epilepsy and those without. Although bMRI revealed that patients with PTE were more likely to present with intracortical lesions (p = 0.02), no differences in the size of the lesion were found between the groups (p = 0.19). Increased BBB permeability was found in 76.9% of patients with PTE compared with 33.3% of patients without epilepsy (p = 0.047), and could be observed years following the trauma. Cerebral cortex volume with BBB disruption was larger in patients with PTE (p = 0.001). In 70% of patients, slow (delta band) activity was co-localised, by sLORETA, with regions showing BBB disruption. Conclusions: Lasting BBB pathology is common in patients with mild TBI, with increased frequency and extent being observed in patients with PTE. A correlation between disrupted BBB and abnormal neuronal activity is suggested. |
| تواريخ الأحداث: | Date Created: 20071110 Date Completed: 20080708 Latest Revision: 20171114 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1136/jnnp.2007.126425 |
| PMID: | 17991703 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-330X |
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| DOI: | 10.1136/jnnp.2007.126425 |