دورية أكاديمية
PGE(2) in pancreatic cyst fluid helps differentiate IPMN from MCN and predict IPMN dysplasia.
| العنوان: | PGE(2) in pancreatic cyst fluid helps differentiate IPMN from MCN and predict IPMN dysplasia. |
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| المؤلفون: | Schmidt CM; Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. maxschmi@iupui.edu, Yip-Schneider MT, Ralstin MC, Wentz S, DeWitt J, Sherman S, Howard TJ, McHenry L, Dutkevitch S, Goggins M, Nakeeb A, Lillemoe KD |
| المصدر: | Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract [J Gastrointest Surg] 2008 Feb; Vol. 12 (2), pp. 243-9. Date of Electronic Publication: 2007 Nov 20. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B.V Country of Publication: United States NLM ID: 9706084 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1091-255X (Print) Linking ISSN: 1091255X NLM ISO Abbreviation: J Gastrointest Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024-: [Amsterdam] : Elsevier B.V. Original Publication: St. Louis, MO : Quality Medical Pub., c1997- |
| مواضيع طبية MeSH: | Carcinoma, Pancreatic Ductal/*diagnosis , Carcinoma, Pancreatic Ductal/*metabolism , Carcinoma, Papillary/*diagnosis , Carcinoma, Papillary/*metabolism , Dinoprostone/*metabolism , Pancreatic Cyst/*metabolism , Pancreatic Neoplasms/*diagnosis , Pancreatic Neoplasms/*metabolism, Adenocarcinoma/diagnosis ; Adenocarcinoma/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Papillary/pathology ; Diagnosis, Differential ; Enzyme-Linked Immunosorbent Assay ; Humans |
| مستخلص: | Current management of intraductal papillary mucinous neoplasm (IPMN) according to recently published International Consensus Guidelines depends upon distinguishing it from mucinous cystic neoplasms (MCNs). We have previously shown that prostaglandin E(2) (PGE(2)) is increased in pancreatic cancer tissue over normal controls. Thus, we hypothesized that PGE(2) level in pancreatic fluid differentiates IPMN and MCN and is a biomarker of IPMN dysplasia. Pancreatic fluid was collected in 65 patients at the time of endoscopy (EUS or ERCP) or operation (OR) and analyzed by PGE(2) enzyme-linked immunosorbent assay (ELISA). PGE(2) level was correlated with surgical pathologic diagnosis and dysplastic stage. Mean PGE(2) level (pg/microl) in IPMNs (2.2 +/- 0.6) was greater than in MCNs (0.2 +/- 0.1) (p < 0.05). Mean PGE(2) level of IPMN by dysplastic stage was 0.1 +/- 0.01 (low grade), 1.2 +/- 0.6 (medium grade), 4.4 +/- 0.9 (high grade), and 5.0 +/- 2.3 (invasive). Among invasive IPMN, PGE(2) level dropped in advanced cases with pancreatic ductal obstruction by tumor (0.3 +/- 0) vs non-obstructed (8.6 +/- 2.9). PGE(2) level may help in distinguishing IPMN from MCN in patients with known mucinous lesions. PGE(2) level may also be an indicator of malignant progression of IPMN before ductal obstruction by tumor. Prospective evaluation will be necessary to evaluate the clinical role of PGE(2) level in pancreatic fluid. |
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| معلومات مُعتمدة: | 1 R03 CA 112629-01A1 United States CA NCI NIH HHS |
| المشرفين على المادة: | K7Q1JQR04M (Dinoprostone) |
| تواريخ الأحداث: | Date Created: 20071121 Date Completed: 20080724 Latest Revision: 20240213 |
| رمز التحديث: | 20240213 |
| DOI: | 10.1007/s11605-007-0404-8 |
| PMID: | 18027059 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1091-255X |
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| DOI: | 10.1007/s11605-007-0404-8 |