دورية أكاديمية
Effect of tangerine juice on cyclosporine levels in renal transplant children.
| العنوان: | Effect of tangerine juice on cyclosporine levels in renal transplant children. |
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| المؤلفون: | Sorkhi H; Department of Pediatric Nephrology, Pediatric Research Center, Amirkola Children's Hospital, Faculty of Medicine, Babol University of Medical Sciences, Babol 47317-41151, Iran. hadisorkhi@yahoo.com, Moghadamnia AA, Oaliaee F, Pouramir M, Firoozjahi AR, Pasha AA, Goodarzi MR |
| المصدر: | Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2008 Mar; Vol. 23 (3), pp. 499-501. Date of Electronic Publication: 2007 Nov 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0931-041X (Print) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer International Original Publication: Berlin : Springer International, c1987- |
| مواضيع طبية MeSH: | Beverages* , Citrus* , Kidney Transplantation*, Cyclosporine/*blood , Immunosuppressive Agents/*blood, Adolescent ; Child ; Cyclosporine/pharmacokinetics ; Female ; Humans ; Immunosuppressive Agents/pharmacokinetics ; Male |
| مستخلص: | The aim of our study was to investigate the effect of tangerine juice on the pharmacokinetics of cyclosporine A (CsA), in children who had received a renal transplant. This placebo-controlled study was done on ten kidney transplant recipients with stable cyclosporine trough levels who received either tangerine (Unshio Satsuma) juice or water. Patients were given their morning doses of CsA and then 250 ml water or the juice, and 12 h, investigations of the pharmacokinetics (PK) were performed. The main outcome measures were peak concentration and time to peak and area under the concentration-time curve. Administration of CsA with tangerine juice compared with water did not increase significantly the area under the whole-blood concentration versus time curve from 0-12 h (AUC(0-12)) of CsA, (tangerine juice 2,797 +/- 1,361 (P = 0.5); water 3,053 +/- 1,532). Co-administration of tangerine juice with CsA compared with water had no significant effects on the AUC(0-12), peak concentration (C(max)) or time to C(max) (t(max)) of the CsA in pediatric renal transplantation. |
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| المشرفين على المادة: | 0 (Immunosuppressive Agents) 83HN0GTJ6D (Cyclosporine) |
| تواريخ الأحداث: | Date Created: 20071122 Date Completed: 20080715 Latest Revision: 20211020 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s00467-007-0655-3 |
| PMID: | 18030500 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0931-041X |
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| DOI: | 10.1007/s00467-007-0655-3 |