دورية أكاديمية
Send in the clamps: control of DNA translesion synthesis in eukaryotes.
العنوان: | Send in the clamps: control of DNA translesion synthesis in eukaryotes. |
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المؤلفون: | Jansen JG; Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands., Fousteri MI, de Wind N |
المصدر: | Molecular cell [Mol Cell] 2007 Nov 30; Vol. 28 (4), pp. 522-9. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Print ISSN: 1097-2765 (Print) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Cambridge Ma : Cell Press Original Publication: Cambridge, Mass. : Cell Press, c1997- |
مواضيع طبية MeSH: | DNA Replication*, DNA/*biosynthesis , Eukaryotic Cells/*metabolism, DNA Damage ; DNA-Directed DNA Polymerase/metabolism ; Eukaryotic Cells/enzymology ; Mutagenesis ; Proliferating Cell Nuclear Antigen/metabolism ; Templates, Genetic ; Ubiquitin/metabolism |
مستخلص: | The replication of damaged DNA templates by translesion synthesis (TLS) is associated with mutagenesis and carcinogenesis. This perspective discusses the different levels at which TLS may be controlled and proposes a model for TLS of severely helix-distorting DNA lesions that includes a decisive role for the Rad9-Hus1-Rad1 DNA-damage-signaling clamp. The dual involvement of this clamp in both DNA-damage signaling and TLS may have profound implications in determining cellular responses to DNA damage. |
المشرفين على المادة: | 0 (Proliferating Cell Nuclear Antigen) 0 (Ubiquitin) 9007-49-2 (DNA) EC 2.7.7.7 (DNA-Directed DNA Polymerase) |
تواريخ الأحداث: | Date Created: 20071129 Date Completed: 20080123 Latest Revision: 20071128 |
رمز التحديث: | 20240628 |
DOI: | 10.1016/j.molcel.2007.11.005 |
PMID: | 18042449 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1097-2765 |
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DOI: | 10.1016/j.molcel.2007.11.005 |