دورية أكاديمية
أعرض في EDS

Send in the clamps: control of DNA translesion synthesis in eukaryotes.

التفاصيل البيبلوغرافية
العنوان: Send in the clamps: control of DNA translesion synthesis in eukaryotes.
المؤلفون: Jansen JG; Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands., Fousteri MI, de Wind N
المصدر: Molecular cell [Mol Cell] 2007 Nov 30; Vol. 28 (4), pp. 522-9.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Print ISSN: 1097-2765 (Print) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge Ma : Cell Press
Original Publication: Cambridge, Mass. : Cell Press, c1997-
مواضيع طبية MeSH: DNA Replication*, DNA/*biosynthesis , Eukaryotic Cells/*metabolism, DNA Damage ; DNA-Directed DNA Polymerase/metabolism ; Eukaryotic Cells/enzymology ; Mutagenesis ; Proliferating Cell Nuclear Antigen/metabolism ; Templates, Genetic ; Ubiquitin/metabolism
مستخلص: The replication of damaged DNA templates by translesion synthesis (TLS) is associated with mutagenesis and carcinogenesis. This perspective discusses the different levels at which TLS may be controlled and proposes a model for TLS of severely helix-distorting DNA lesions that includes a decisive role for the Rad9-Hus1-Rad1 DNA-damage-signaling clamp. The dual involvement of this clamp in both DNA-damage signaling and TLS may have profound implications in determining cellular responses to DNA damage.
المشرفين على المادة: 0 (Proliferating Cell Nuclear Antigen)
0 (Ubiquitin)
9007-49-2 (DNA)
EC 2.7.7.7 (DNA-Directed DNA Polymerase)
تواريخ الأحداث: Date Created: 20071129 Date Completed: 20080123 Latest Revision: 20071128
رمز التحديث: 20240628
DOI: 10.1016/j.molcel.2007.11.005
PMID: 18042449
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-2765
DOI:10.1016/j.molcel.2007.11.005