دورية أكاديمية
Reference values for kaolin-activated thromboelastography in healthy children.
| العنوان: | Reference values for kaolin-activated thromboelastography in healthy children. |
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| المؤلفون: | Chan KL; Department of Clinical Hematology, Royal Children's Hospital, Melbourne, Australia., Summerhayes RG, Ignjatovic V, Horton SB, Monagle PT |
| المصدر: | Anesthesia and analgesia [Anesth Analg] 2007 Dec; Vol. 105 (6), pp. 1610-3, table of contents. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1310650 Publication Model: Print Cited Medium: Internet ISSN: 1526-7598 (Electronic) Linking ISSN: 00032999 NLM ISO Abbreviation: Anesth Analg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins Original Publication: Cleveland, International Anesthesia Research Society. |
| مواضيع طبية MeSH: | Kaolin/*pharmacology , Thrombelastography/*drug effects , Thrombelastography/*standards, Adolescent ; Adult ; Blood Coagulation/physiology ; Blood Coagulation Tests/methods ; Blood Coagulation Tests/standards ; Child ; Child, Preschool ; Humans ; Infant ; Middle Aged ; Reference Values ; Thrombelastography/methods |
| مستخلص: | Background: The hemostatic system of children changes with age and differs significantly from the hemostatic system of adults. Age-specific reference values are therefore required for most hemostatic variables. Thromboelastography (TEG) is a point-of-care coagulation test that may provide superior evaluation and management of coagulopathies after cardiac surgery, when large-dose unfractionated heparin is administered for cardiopulmonary bypass. In this study, we established reference values for kaolin-activated TEG in healthy children, to facilitate accurate interpretation of pediatric TEG results. Methods: Kaolin-activated TEG was performed on 100 healthy children undergoing elective day surgery and 25 healthy adult volunteers. The following TEG variables were recorded: reaction time, coagulation time, alpha angle, maximum amplitude, percentage lysis 30 min after maximum amplitude was reached, and the coagulation index. Differences between age-groups were evaluated using analysis of variance. Results: Age-specific reference values for kaolin-activated TEG in healthy children between 1 mo and 16 yr of age are presented. No significant differences between children and adults were observed. Conclusions: TEG results, from a particular clinical setting, must be compared to age-specific, as well as analyzer- and activator-specific, reference values to allow for correct interpretation of the results. Reference values provided here will be of use in acute clinical situations where a practical monitor of hemostasis is required. |
| المشرفين على المادة: | 24H4NWX5CO (Kaolin) |
| تواريخ الأحداث: | Date Created: 20071129 Date Completed: 20071220 Latest Revision: 20220410 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1213/01.ane.0000287645.26763.be |
| PMID: | 18042858 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1526-7598 |
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| DOI: | 10.1213/01.ane.0000287645.26763.be |