دورية أكاديمية
[Comparative toxicity of photosensitizers in varying destruction].
| العنوان: | [Comparative toxicity of photosensitizers in varying destruction]. |
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| المؤلفون: | Sinitsina OO, Zholdakova ZI, Poliakova EE, Golovach EN, Sycheva LP, Beliaeva NN, Kuznetsova NA |
| المصدر: | Gigiena i sanitariia [Gig Sanit] 2007 Sep-Oct (5), pp. 57-60. |
| نوع المنشور: | Comparative Study; English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Izdatelstvo Meditsina Country of Publication: Russia (Federation) NLM ID: 0412700 Publication Model: Print Cited Medium: Print ISSN: 0016-9900 (Print) Linking ISSN: 00169900 NLM ISO Abbreviation: Gig Sanit Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Izdatelstvo Meditsina Original Publication: Moskva, Meditsina [etc.] |
| مواضيع طبية MeSH: | Duodenum/*drug effects , Kidney/*drug effects , Liver/*drug effects , Photosensitizing Agents/*toxicity, Animals ; Disease Models, Animal ; Disinfection/methods ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/toxicity ; Male ; Methylene Blue/chemistry ; Methylene Blue/toxicity ; Mice ; Mice, Inbred BALB C ; Photosensitizing Agents/chemistry ; Proflavine/chemistry ; Proflavine/toxicity ; Rats |
| مستخلص: | The toxicity of the photosensitizers proflavine acetate (PA) versus methylene blue (MB) was evaluated during their varying destruction. Under the influence of visible light, a partial (25%) transformation of the photosensitizers was shown to be attended by their enhanced toxicity and 100% destruction of the parent substances caused a reduction in their hazard. PA and its phototransformation products mainly affect the antiperoxide protection system and the structural and functional states of the liver, kidney, and duodenum. The maximum noneffective dose is 0.002 mg/kg. The possibility of using PA for water disinfection depends on the ratio of safe and effective concentrations. A partial (25%) MB destruction products cause mutagenic effects; the permissible dose of the mutagen is 0.00025 mg/kg. MB is not recommended for disinfection of all types of waters. |
| المشرفين على المادة: | 0 (Enzyme Inhibitors) 0 (Photosensitizing Agents) CY3RNB3K4T (Proflavine) T42P99266K (Methylene Blue) |
| تواريخ الأحداث: | Date Created: 20071207 Date Completed: 20080103 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| PMID: | 18050705 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0016-9900 |
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