دورية أكاديمية
A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon.
| العنوان: | A repetitive region of gammaherpesvirus genomic DNA is a ligand for induction of type I interferon. |
|---|---|
| المؤلفون: | Sanchez DJ; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA., Miranda D Jr, Arumugaswami V, Hwang S, Singer AE, Senaati A, Shahangian A, Song MJ, Sun R, Cheng G |
| المصدر: | Journal of virology [J Virol] 2008 Mar; Vol. 82 (5), pp. 2208-17. Date of Electronic Publication: 2007 Dec 12. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Society For Microbiology Original Publication: Baltimore, American Society for Microbiology. |
| مواضيع طبية MeSH: | DNA, Viral/*genetics , Gammaherpesvirinae/*genetics , Interferon Type I/*biosynthesis, Animals ; Base Sequence ; Cells, Cultured ; Chromosomes, Artificial, Bacterial ; DNA Primers ; DNA, Viral/metabolism ; Humans ; Ligands ; Mice ; Mutation |
| مستخلص: | Innate immune responses against viral infection, especially the induction of type I interferon, are critical for limiting the replication of the virus. Although it has been shown that DNA can induce type I interferon, to date no natural DNA ligand of a virus that induces type I interferon has been described. Here we screened the genome of murine gammaherpesvirus 68 with mutations at various genomic locations to map the region of DNA that induces type I interferon. A repetitive region termed the 100-base-pair repeat region is a ligand that is both necessary and sufficient for the viral genomic DNA to induce type I interferon. A region colinear with this ligand in the genome of Kaposi's sarcoma-associated herpesvirus also induces type I interferon. We have thus defined a repetitive region of the genomes of gammaherpesviruses as the first natural DNA virus ligand that induces type I interferon. |
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| معلومات مُعتمدة: | R0I-AI069120 United States AI NIAID NIH HHS; 5T32AI007126-30 United States AI NIAID NIH HHS; 5 T32 CA009056-29 United States CA NCI NIH HHS; T32 CA009056 United States CA NCI NIH HHS; R01 AI069120 United States AI NIAID NIH HHS; T32 AI007126 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (DNA Primers) 0 (DNA, Viral) 0 (Interferon Type I) 0 (Ligands) |
| تواريخ الأحداث: | Date Created: 20071214 Date Completed: 20080331 Latest Revision: 20240414 |
| رمز التحديث: | 20240414 |
| مُعرف محوري في PubMed: | PMC2258961 |
| DOI: | 10.1128/JVI.01718-07 |
| PMID: | 18077715 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-5514 |
|---|---|
| DOI: | 10.1128/JVI.01718-07 |