دورية أكاديمية
Results from a randomized controlled trial of a peer-mentoring intervention to reduce HIV transmission and increase access to care and adherence to HIV medications among HIV-seropositive injection drug users.
| العنوان: | Results from a randomized controlled trial of a peer-mentoring intervention to reduce HIV transmission and increase access to care and adherence to HIV medications among HIV-seropositive injection drug users. |
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| المؤلفون: | Purcell DW; Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. dpurcell@cdc.gov, Latka MH, Metsch LR, Latkin CA, Gómez CA, Mizuno Y, Arnsten JH, Wilkinson JD, Knight KR, Knowlton AR, Santibanez S, Tobin KE, Rose CD, Valverde EE, Gourevitch MN, Eldred L, Borkowf CB |
| مؤلفون مشاركون: | INSPIRE Study Team |
| المصدر: | Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2007 Nov 01; Vol. 46 Suppl 2, pp. S35-47. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 100892005 Publication Model: Print Cited Medium: Print ISSN: 1525-4135 (Print) Linking ISSN: 15254135 NLM ISO Abbreviation: J Acquir Immune Defic Syndr Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, Inc., c1999- |
| مواضيع طبية MeSH: | Health Services Accessibility* , Patient Compliance* , Substance Abuse, Intravenous*, Communicable Disease Control/*methods , HIV Infections/*drug therapy , HIV Infections/*prevention & control, Adult ; Behavior Control/methods ; CD4 Lymphocyte Count ; Female ; HIV Infections/epidemiology ; HIV Infections/transmission ; Humans ; Male ; Middle Aged ; Risk-Taking ; Treatment Outcome ; United States/epidemiology ; Viral Load |
| مستخلص: | Background: There is a lack of effective behavioral interventions for HIV-positive injection drug users (IDUs). We sought to evaluate the efficacy of an intervention to reduce sexual and injection transmission risk behaviors and to increase utilization of medical care and adherence to HIV medications among this population. Methods: HIV-positive IDUs (n=966) recruited in 4 US cities were randomly assigned to a 10-session peer mentoring intervention or to an 8-session video discussion intervention (control condition). Participants completed audio computer-assisted self-interviews and had their blood drawn to measure CD4 cell count and viral load at baseline and at 3-month (no blood), 6-month, and 12-month follow-ups. Results: Overall retention rates for randomized participants were 87%, 83%, and 85% at 3, 6, and 12 months, respectively. Participants in both conditions reported significant reductions from baseline in injection and sexual transmission risk behaviors, but there were no significant differences between conditions. Participants in both conditions reported no change in medical care and adherence, and there were no significant differences between conditions. Conclusions: Both interventions led to decreases in risk behaviors but no changes in medical outcomes. The characteristics of the trial that may have contributed to these results are examined, and directions for future research are identified. |
| سلسلة جزيئية: | ClinicalTrials.gov NCT00146445 |
| تواريخ الأحداث: | Date Created: 20080103 Date Completed: 20080117 Latest Revision: 20200930 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/QAI.0b013e31815767c4 |
| PMID: | 18089983 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1525-4135 |
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| DOI: | 10.1097/QAI.0b013e31815767c4 |