A high rate of CLL phenotype lymphocytes in autoimmune hemolytic anemia and immune thrombocytopenic purpura.

التفاصيل البيبلوغرافية
العنوان:	A high rate of CLL phenotype lymphocytes in autoimmune hemolytic anemia and immune thrombocytopenic purpura.
المؤلفون:	Mittal S, Blaylock MG, Culligan DJ, Barker RN, Vickers MA
المصدر:	Haematologica [Haematologica] 2008 Jan; Vol. 93 (1), pp. 151-2.
نوع المنشور:	Letter; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE
أسماء مطبوعة:	Publication: 1999- : Pavia, Italy : Ferrata Storti Foundation Original Publication: Pavia [etc.]
مواضيع طبية MeSH:	Anemia, Hemolytic, Autoimmune/blood , Leukemia, Lymphocytic, Chronic, B-Cell/genetics , Lymphocytes/metabolism , Purpura, Thrombocytopenic, Idiopathic/blood, Adult ; Aged ; Aged, 80 and over ; Anemia, Hemolytic, Autoimmune/genetics ; Case-Control Studies ; Cell Separation ; Flow Cytometry ; Humans ; Middle Aged ; Phenotype ; Purpura, Thrombocytopenic, Idiopathic/genetics ; Syndrome
مستخلص:	Minor CLL-like clones are found in approximately 3% of healthy individuals. AIHA and ITP are common in CLL and may be causally linked. We investigated the presence of CLL phenotype lymphocytes in 11 cases of primary AIHA, 18 of ITP and 2 of Evans' Syndrome, compared with 26 age-matched healthy controls. A population of 'CLL phenotype' was seen in 6/31 patients compared to 1/26 healthy controls (chi(2)=3.9; p=0.05). Such clones may be important in the pathogenesis of autoimmune blood disorders.
تواريخ الأحداث:	Date Created: 20080102 Date Completed: 20080423 Latest Revision: 20080101
رمز التحديث:	20240628
DOI:	10.3324/haematol.11822
PMID:	18166805
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1592-8721
DOI:	10.3324/haematol.11822