دورية أكاديمية
Antibacterial activity of pyrrolidine dithiocarbamate.
| العنوان: | Antibacterial activity of pyrrolidine dithiocarbamate. |
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| المؤلفون: | Kang MS; Brain Korea 21 Program, Chonnam National University, Kwangju, South Korea., Choi EK, Choi DH, Ryu SY, Lee HH, Kang HC, Koh JT, Kim OS, Hwang YC, Yoon SJ, Kim SM, Yang KH, Kang IC |
| المصدر: | FEMS microbiology letters [FEMS Microbiol Lett] 2008 Mar; Vol. 280 (2), pp. 250-4. Date of Electronic Publication: 2008 Jan 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 7705721 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0378-1097 (Print) Linking ISSN: 03781097 NLM ISO Abbreviation: FEMS Microbiol Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Oxford Oxford University Press Original Publication: Amsterdam, Published by Elsevier/North Holland on behalf of the Federation of European Microbiological Societies. |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Bacteria/*drug effects , Chelating Agents/*pharmacokinetics , Pyrrolidines/*pharmacology , Thiocarbamates/*pharmacology, Bacteria/metabolism ; Chlorides/metabolism ; Copper/metabolism ; Zinc Compounds/metabolism |
| مستخلص: | Pyrrolidine dithiocarbamate (PDTC), an antioxidant with a metal-chelating activity, has been used widely to inhibit the expression of inflammatory genes in vitro and in vivo. This study investigated whether PDTC has an antimicrobial activity against various bacteria. The antibacterial activity of PDTC and other compounds was evaluated in vitro by the broth microdilution method against Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Staphylococcus aureus, and Escherichia coli. Bacterial growth was inhibited by PDTC, where a wide range of sensitivity was demonstrated among the tested bacteria. The antibacterial activity of PDTC was reduced by the addition of copper chloride; in contrast, it was enhanced considerably by zinc chloride. Two different zinc chelators, Ca-saturated EDTA (Ca-EDTA) and N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, blocked the antibacterial activity of PDTC, whereas Zn-EDTA failed to reduce the activity of PDTC. These results demonstrate for the first time that PDTC possesses an antibacterial activity, for which zinc is required, and suggest that PDTC, possessing a dual anti-inflammatory and antibacterial activity, may be considered for topical use for inflammatory diseases of bacterial origin. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Chelating Agents) 0 (Chlorides) 0 (Pyrrolidines) 0 (Thiocarbamates) 0 (Zinc Compounds) 25769-03-3 (pyrrolidine dithiocarbamic acid) 789U1901C5 (Copper) 86Q357L16B (zinc chloride) |
| تواريخ الأحداث: | Date Created: 20080206 Date Completed: 20080813 Latest Revision: 20131121 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1111/j.1574-6968.2008.01069.x |
| PMID: | 18248425 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0378-1097 |
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| DOI: | 10.1111/j.1574-6968.2008.01069.x |