دورية أكاديمية
Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne.
| العنوان: | Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne. |
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| المؤلفون: | Tang NJ; The College of Environmental Science and Engineering, Nankai University, Weijin Road 94#, Tianjin 300071, China. tangnaijun@tijmu.edu.cn, Liu J, Coenraads PJ, Dong L, Zhao LJ, Ma SW, Chen X, Zhang CM, Ma XM, Wei WG, Zhang P, Bai ZP |
| المصدر: | Toxicology letters [Toxicol Lett] 2008 Apr 01; Vol. 177 (3), pp. 182-7. Date of Electronic Publication: 2008 Feb 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0378-4274 (Print) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Amsterdam, Elsevier/North Holland. |
| مواضيع طبية MeSH: | Genes, fos*, Chloracne/*etiology , Cytochrome P-450 CYP1A1/*genetics , Glutathione Transferase/*genetics , Occupational Exposure/*adverse effects , Polychlorinated Dibenzodioxins/*toxicity , Receptors, Aryl Hydrocarbon/*genetics , Skin/*drug effects , Transforming Growth Factor alpha/*genetics, Chloracne/metabolism ; Humans ; Male ; Middle Aged ; Skin/metabolism |
| مستخلص: | Occupational exposure to certain polychlorinated aromatic hydrocarbons such as dioxins has been suggested to cause chloracne which is a kind of skin disease. The molecular mechanisms of dioxin-mediated chloracne have not been clarified. It is possible that dioxins contribute to the pathogenesis through activation of aryl-hydrocarbon receptor (AhR)-mediated transcription and downstream genes such as CYP1A1, GSTA1 and TGF-alpha. The study on genes was through chloracne lesional skin, which has rarely been reported on previously. The expression levels of key genes, such as AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in human epidermal tissue of chloracne cases and controls were detected by real-time PCR. Compared with controls, AhR, CYP1A1, GSTA1 and c-fos transactivations were significantly induced in the skins of chloracne patients who had long-term exposure to dioxins and dibenzofuranes. The TGF-alpha mRNA content of epidermal tissue was increased, but not significantly compared with controls. The study demonstrates that constitutive activation of the AhR pathway is probably a prerequisite of chloracne pathogenesis. The changes of genes expression may disturb normal proliferation and differentiation of human epidermis cells, and then lead to chloracne. |
| المشرفين على المادة: | 0 (Polychlorinated Dibenzodioxins) 0 (Receptors, Aryl Hydrocarbon) 0 (Transforming Growth Factor alpha) EC 1.14.14.1 (Cytochrome P-450 CYP1A1) EC 2.5.1.18 (GSTA1 protein, human) EC 2.5.1.18 (Glutathione Transferase) |
| تواريخ الأحداث: | Date Created: 20080311 Date Completed: 20080605 Latest Revision: 20161124 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.toxlet.2008.01.011 |
| PMID: | 18329192 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0378-4274 |
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| DOI: | 10.1016/j.toxlet.2008.01.011 |