دورية أكاديمية
Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis.
| العنوان: | Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. |
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| المؤلفون: | Zipitis CS; Department of Paediatrics, Stockport NHS Foundation Trust, Poplar Grove, Stockport SK2 7JE, UK. czipitis@hotmail.com, Akobeng AK |
| المصدر: | Archives of disease in childhood [Arch Dis Child] 2008 Jun; Vol. 93 (6), pp. 512-7. Date of Electronic Publication: 2008 Mar 13. |
| نوع المنشور: | Journal Article; Meta-Analysis; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group [etc.] Country of Publication: England NLM ID: 0372434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2044 (Electronic) Linking ISSN: 00039888 NLM ISO Abbreviation: Arch Dis Child Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London :, BMJ Pub. Group [etc.] Original Publication: London : British Medical Association |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 1/*prevention & control , Vitamin D/*administration & dosage , Vitamin D Deficiency/*immunology , Vitamins/*administration & dosage, Adolescent ; Age Factors ; Case-Control Studies ; Child ; Child, Preschool ; Diabetes Mellitus, Type 1/diet therapy ; Dose-Response Relationship, Drug ; Humans ; Infant ; Vitamin D Deficiency/diet therapy |
| مستخلص: | Objectives: To assess whether vitamin D supplementation in infancy reduces the risk of type 1 diabetes in later life. Methods: This was a systematic review and meta-analysis using Medline, Embase, Cinahl, Cochrane Central Register of Controlled Trials and reference lists of retrieved articles. The main outcome measure was development of type 1 diabetes. Controlled trials and observational studies that had assessed the effect of vitamin D supplementation on risk of developing type 1 diabetes were included in the analysis. Results: Five observational studies (four case-control studies and one cohort study) met the inclusion criteria; no randomised controlled trials were found. Meta-analysis of data from the case-control studies showed that the risk of type 1 diabetes was significantly reduced in infants who were supplemented with vitamin D compared to those who were not supplemented (pooled odds ratio 0.71, 95% CI 0.60 to 0.84). The result of the cohort study was in agreement with that of the meta-analysis. There was also some evidence of a dose-response effect, with those using higher amounts of vitamin D being at lower risk of developing type 1 diabetes. Finally, there was a suggestion that the timing of supplementation might also be important for the subsequent development of type 1 diabetes. Conclusion: Vitamin D supplementation in early childhood may offer protection against the development of type 1 diabetes. The evidence for this is based on observational studies. Adequately powered, randomised controlled trials with long periods of follow-up are needed to establish causality and the best formulation, dose, duration and period of supplementation. |
| Number of References: | 38 |
| المشرفين على المادة: | 0 (Vitamins) 1406-16-2 (Vitamin D) |
| تواريخ الأحداث: | Date Created: 20080315 Date Completed: 20080620 Latest Revision: 20220408 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1136/adc.2007.128579 |
| PMID: | 18339654 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1468-2044 |
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| DOI: | 10.1136/adc.2007.128579 |