دورية أكاديمية
أعرض في EDS

Anti-tuberculosis therapy-induced hepatotoxicity among Ethiopian HIV-positive and negative patients.

التفاصيل البيبلوغرافية
العنوان: Anti-tuberculosis therapy-induced hepatotoxicity among Ethiopian HIV-positive and negative patients.
المؤلفون: Yimer G; Armauer Hansen Research Institute, Addis Ababa, Ethiopia., Aderaye G, Amogne W, Makonnen E, Aklillu E, Lindquist L, Yamuah L, Feleke B, Aseffa A
المصدر: PloS one [PLoS One] 2008 Mar 19; Vol. 3 (3), pp. e1809. Date of Electronic Publication: 2008 Mar 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: HIV Seronegativity*, Antitubercular Agents/*adverse effects , Chemical and Drug Induced Liver Injury/*etiology , HIV Infections/*complications , Tuberculosis/*drug therapy, Adolescent ; Adult ; Aged ; Cohort Studies ; Ethiopia ; Female ; Humans ; Male ; Middle Aged ; Tuberculosis/complications
مستخلص: Background: To assess and compare the prevalence, severity and prognosis of anti-TB drug induced hepatotoxicity (DIH) in HIV positive and HIV negative tuberculosis (TB) patients in Ethiopia.
Methodology/principal Findings: In this study, 103 HIV positive and 94 HIV negative TB patients were enrolled. All patients were evaluated for different risk factors and monitored biochemically and clinically for development of DIH. Sub-clinical hepatotoxicity was observed in 17.3% of the patients and 8 out of the 197 (4.1%) developed clinical hepatotoxicity. Seven of the 8 were HIV positive and 2 were positive for HBsAg.
Conclusions/significance: Sub-clinical hepatotoxicity was significantly associated with HIV co-infection (p = 0.002), concomitant drug intake (p = 0.008), and decrease in CD4 count (p = 0.001). Stepwise restarting of anti TB treatment was also successful in almost all the patients who developed clinical DIH. We therefore conclude that anti-TB DIH is a major problem in HIV-associated TB with a decline in immune status and that there is a need for a regular biochemical and clinical follow up for those patients who are at risk.
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المشرفين على المادة: 0 (Antitubercular Agents)
تواريخ الأحداث: Date Created: 20080320 Date Completed: 20080808 Latest Revision: 20211020
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC2265547
DOI: 10.1371/journal.pone.0001809
PMID: 18350147
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0001809