دورية أكاديمية
[Disorders of the hypothalamo-hypophyseal system as a cause of infertility in hyperprolactinemia].
| العنوان: | [Disorders of the hypothalamo-hypophyseal system as a cause of infertility in hyperprolactinemia]. |
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| عنوان ترانسليتريتد: | Narushenie gipotalmo-gipofizarníkh vzaimosviazeĭ, kak prichina vesplodiia pri giperprolaktinemii. |
| المؤلفون: | Stepanskaia NV, Ovsiannikova TV, Pshenichnikova TIa |
| المصدر: | Acta Universitatis Palackianae Olomucensis Facultatis Medicae [Acta Univ Palacki Olomuc Fac Med] 1991; Vol. 129, pp. 163-73. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Statni Pedogogicke Nakladatelstiv Country of Publication: Czech Republic NLM ID: 0363112 Publication Model: Print Cited Medium: Print ISSN: 0301-2514 (Print) Linking ISSN: 03012514 NLM ISO Abbreviation: Acta Univ Palacki Olomuc Fac Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Praha : Statni Pedogogicke Nakladatelstiv Original Publication: Praha, Státní pedagogické naklad. |
| مواضيع طبية MeSH: | Hyperprolactinemia/*physiopathology , Hypothalamo-Hypophyseal System/*physiopathology , Infertility, Female/*etiology, Adult ; Female ; Humans ; Hyperprolactinemia/blood ; Hyperprolactinemia/complications ; Infertility, Female/blood ; Pituitary Hormones/blood ; Pregnancy |
| مستخلص: | The purpose of the study was to describe hypothalamopituitary functional status of females with infertility in combination with hyperprolactinemia. To this end, changes in prolactin, LH, FSH and TSH in response to the administration of releasing hormones (Gn--RH and TRH) and the dopamine antagonist metoclopramide were assessed in 28 patients with hyperprolactinemic amenorrhea and 5 normal cycling women. Lactotrophs were found to be resistant to functional tests, the resistance increasing as the prolactin level went up. Gonadotrophic and thyrotrophic response to functional tests, on the contrary, increased with the progress of hyperprolactinemia. A conclusion is drawn that stable hyperprolactinemia is a result of disturbance in lactotrophic receptor apparatus, for which reason lactotrophs are no longer sensitive to dophamine inhibiting effect on prolactin secretion. |
| المشرفين على المادة: | 0 (Pituitary Hormones) |
| تواريخ الأحداث: | Date Created: 19910101 Date Completed: 19920227 Latest Revision: 20061115 |
| رمز التحديث: | 20221208 |
| PMID: | 1837659 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0301-2514 |
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