دورية أكاديمية
أعرض في EDS

High prevalence of hypovitaminosis D and secondary hyperparathyroidism in elders living in nonprofit homes in South Brazil.

التفاصيل البيبلوغرافية
العنوان: High prevalence of hypovitaminosis D and secondary hyperparathyroidism in elders living in nonprofit homes in South Brazil.
المؤلفون: Scalco R; Post-graduation Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul and Serviço de Patologia Clínica do Hospital de Clínicas de Porto Alegre , Rua Ramiro Barcellos 2400, Porto Alegre, RS, 90035-003, Brazil. roscalco@yahoo.com.br, Premaor MO, Fröehlich PE, Furlanetto TW
المصدر: Endocrine [Endocrine] 2008 Feb; Vol. 33 (1), pp. 95-100. Date of Electronic Publication: 2008 Apr 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9434444 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1355-008X (Print) Linking ISSN: 1355008X NLM ISO Abbreviation: Endocrine Subsets: MEDLINE
أسماء مطبوعة: Publication: Feb. 1996- : Totowa, NJ : Humana Press
Original Publication: Houndsmills, Basingstoke, Hants, UK : Macmillan Press, c1994-
مواضيع طبية MeSH: Aged* , Organizations, Nonprofit* , Residence Characteristics*, Hyperparathyroidism, Secondary/*epidemiology , Vitamin D Deficiency/*epidemiology, Aged, 80 and over ; Brazil/epidemiology ; Cholecalciferol/analysis ; Cholecalciferol/blood ; Female ; Humans ; Hyperparathyroidism, Secondary/blood ; Male ; Parathyroid Hormone/blood ; Prevalence ; Vitamin D Deficiency/blood
مستخلص: Objectives: Hypovitaminosis D (HD) and secondary hyperparathyroidism (SHP) are common in elders, and many factors could contribute to them. The objectives of this study were to estimate the prevalence of HD, SHP, and its associated factors, in individuals living in nonprofit homes for elders in south Brazil. Design Cross-sectional study.
Methods: Serum 25-hydroxyvitamin D 25(OH)D, intact parathyroid hormone (PTH), total calcium, phosphorus, alkaline phosphatase, magnesium, creatinine, and albumin levels were measured in late spring, November, 2005. The presence of factors potentially related with HD and SHP-age, sex, weight, height, skin phototype, sun exposure, exercise, smoking, use of < or = 5 medications or diuretics or alcohol, and daily calcium ingestion.
Results: 102 subjects age 77.8 +/- 9.0 were included in the study. HD was found in 85.7% and SHP in 53% of the subjects. The estimated daily calcium ingestion was 720 mg. There was no association between serum 25(OH)D levels and any of the risk factors evaluated. Serum 25(OH)D levels were correlated with serum PTH (r = -0.358, P = 0.000), calcium (r = 0.306, P = 0.002), and albumin (r = 0.253, P = 0.011) levels. In univariate analysis, SHP was positively associated with age (P = 0.006), and female sex (0.007); and negatively associated with sunlight exposure (P = 0.020), GFR (P = 0.000), Ln25(OH)D (P = 0.002), and total serum calcium (P = 0.024). After multivariate model adjustment, age [OR 1.09 (CI 1.01-1.18); P = 0.024], Ln25(OH)D [OR 0.92 (CI 0.08-0.74); P = 0.013], GFR [OR 0.96 (CI 0.92-0.99); P = 0.013], and hydrochlorothiazide treatment [OR 7.63 (CI 1.67-34.9); P = 0.008] were independently associated with SHP.
Conclusions: HD and SHP are highly prevalent in elders living in old-age homes. No associations were established between common risk factors and low serum levels of 25(OH)D levels; however, SHP was independently related with age, 25(OH)D, GFR, and hydrochlorothiazide use.
References: J Am Soc Nephrol. 2007 Sep;18(9):2509-16. (PMID: 17656470)
J Am Geriatr Soc. 2007 Jun;55(6):816-23. (PMID: 17537080)
Arq Bras Endocrinol Metabol. 2007 Apr;51(3):437-42. (PMID: 17546243)
Nature. 1987 Jan 1-7;325(6099):62-5. (PMID: 3025747)
N Engl J Med. 2007 Jul 19;357(3):266-81. (PMID: 17634462)
Age Ageing. 2001 Nov;30(6):467-72. (PMID: 11742774)
J Clin Endocrinol Metab. 2003 Jan;88(1):185-91. (PMID: 12519850)
J Invest Dermatol. 2004 Feb;122(2):xxx-xxxi. (PMID: 15009759)
Osteoporos Int. 2005 Dec;16(12):1649-54. (PMID: 15947862)
J Intern Med. 2006 Sep;260(3):245-54. (PMID: 16918822)
JAMA. 2005 May 11;293(18):2257-64. (PMID: 15886381)
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):614-9. (PMID: 17227709)
Calcif Tissue Int. 2007 Apr;80(4):221-6. (PMID: 17431533)
Prog Biophys Mol Biol. 2006 Sep;92(1):17-25. (PMID: 16766240)
J Bone Miner Metab. 2006;24(5):395-400. (PMID: 16937272)
JAMA. 2005 Nov 9;294(18):2336-41. (PMID: 16278362)
Clin Endocrinol (Oxf). 2001 May;54(5):583-92. (PMID: 11380488)
Am J Clin Nutr. 1984 Apr;39(4):625-30. (PMID: 6608872)
Osteoporos Int. 2006;17(7):1013-21. (PMID: 16596461)
J Clin Invest. 2005 Jun;115(6):1651-8. (PMID: 15902302)
J Endocrinol Invest. 1989 Sep;12(8):531-5. (PMID: 2592738)
J Intern Med. 2001 Aug;250(2):144-53. (PMID: 11489064)
Endocrine. 2004 Jun;24(1):47-53. (PMID: 15249703)
Osteoporos Int. 2005 Dec;16(12):1721-6. (PMID: 15928802)
Clin Endocrinol (Oxf). 2008 Feb;68(2):290-8. (PMID: 17854393)
Bone. 2008 Feb;42(2):267-70. (PMID: 18024243)
Am J Physiol Renal Physiol. 2004 Dec;287(6):F1164-70. (PMID: 15265769)
J Biol Chem. 2005 May 20;280(20):19902-10. (PMID: 15781471)
J Endocrinol Invest. 2008 Nov;31(11):991-5. (PMID: 19169055)
Clin Endocrinol (Oxf). 2005 Mar;62(3):265-81. (PMID: 15730407)
Endocr Rev. 2001 Aug;22(4):477-501. (PMID: 11493580)
J Am Med Dir Assoc. 2007 Jun;8(5):328-31. (PMID: 17570313)
المشرفين على المادة: 0 (Parathyroid Hormone)
1C6V77QF41 (Cholecalciferol)
تواريخ الأحداث: Date Created: 20080411 Date Completed: 20080909 Latest Revision: 20220408
رمز التحديث: 20221213
DOI: 10.1007/s12020-008-9061-2
PMID: 18401764
قاعدة البيانات: MEDLINE
الوصف
تدمد:1355-008X
DOI:10.1007/s12020-008-9061-2