دورية أكاديمية
Medical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization.
| العنوان: | Medical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization. |
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| المؤلفون: | Kwakman PH; Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, The Netherlands., Van den Akker JP, Güçlü A, Aslami H, Binnekade JM, de Boer L, Boszhard L, Paulus F, Middelhoek P, te Velde AA, Vandenbroucke-Grauls CM, Schultz MJ, Zaat SA |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2008 Jun 01; Vol. 46 (11), pp. 1677-82. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Honey*, Anti-Bacterial Agents/*therapeutic use , Bacteria/*drug effects , Skin Diseases, Bacterial/*drug therapy, Anti-Bacterial Agents/pharmacology ; Bacteria/growth & development ; Humans ; Microbial Sensitivity Tests |
| مستخلص: | Background: Antibiotic resistance among microbes urgently necessitates the development of novel antimicrobial agents. Since ancient times, honey has been used successfully for treatment of infected wounds, because of its antibacterial activity. However, large variations in the in vitro antibacterial activity of various honeys have been reported and hamper its acceptance in modern medicine. Methods: We assessed the in vitro bactericidal activity of Revamil (Bfactory), a medical-grade honey produced under controlled conditions, and assessed its efficacy for reduction of forearm skin colonization in healthy volunteers in a within-subject-controlled trial. Results: With Bacillus subtilis as a test strain, we demonstrated that the variation in bactericidal activity of 11 batches of medical-grade honey was <2-fold. Antibiotic-susceptible and -resistant isolates of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, and Klebsiella oxytoca were killed within 24 h by 10%-40% (vol/vol) honey. After 2 days of application of honey, the extent of forearm skin colonization in healthy volunteers was reduced 100-fold (P < .001), and the numbers of positive skin cultures were reduced by 76% (P < .001). Conclusions: Revamil is a promising topical antimicrobial agent for prevention or treatment of infections, including those caused by multidrug-resistant bacteria. |
| التعليقات: | Comment in: Clin Infect Dis. 2008 Sep 1;47(5):730-1. (PMID: 18680399) |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) |
| تواريخ الأحداث: | Date Created: 20080425 Date Completed: 20080721 Latest Revision: 20090416 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1086/587892 |
| PMID: | 18433338 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1086/587892 |