دورية أكاديمية
Semen quality in men with disseminated testicular cancer: relation with human chorionic gonadotropin beta-subunit and pituitary gonadal hormones.
| العنوان: | Semen quality in men with disseminated testicular cancer: relation with human chorionic gonadotropin beta-subunit and pituitary gonadal hormones. |
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| المؤلفون: | de Bruin D; Department of Urology, University of Groningen, University Medical Center, Groningen, The Netherlands. d.de.bruin@uro.umcg.nl, de Jong IJ, Arts EG, Nuver J, Dullaart RP, Sluiter WJ, Hoekstra HJ, Sleijfer DT, Gietema JA |
| المصدر: | Fertility and sterility [Fertil Steril] 2009 Jun; Vol. 91 (6), pp. 2481-6. Date of Electronic Publication: 2008 Apr 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier for the American Society for Reproductive Medicine Country of Publication: United States NLM ID: 0372772 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-5653 (Electronic) Linking ISSN: 00150282 NLM ISO Abbreviation: Fertil Steril Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York. NY : Elsevier for the American Society for Reproductive Medicine Original Publication: New York, Hoeber. |
| مواضيع طبية MeSH: | Chorionic Gonadotropin, beta Subunit, Human/*blood , Estradiol/*blood , Prolactin/*blood , Semen/*physiology , Testicular Neoplasms/*pathology , Testosterone/*blood, Adult ; Cryopreservation/methods ; Follicle Stimulating Hormone/blood ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Orchiectomy ; Semen Preservation/methods ; Sperm Motility ; Testicular Neoplasms/blood ; Testicular Neoplasms/drug therapy ; Young Adult ; alpha-Fetoproteins/metabolism |
| مستخلص: | Objective: To compare the semen quality and hormonal status between patients with testicular cancer and normal versus increased serum levels of beta-hCG. Design: Retrospective study. Setting: Academic research environment. Patient(s): All 203 patients with testicular cancer who required chemotherapy in the period 1995-2003 were included. Intervention(s): In 107 patients semen samples were stored by cryopreservation; 62 patients could be analyzed because both semen was stored and hormones were determined before starting chemotherapy (median age 25 years, range 17-49 years). Main Outcome Measure(s): Total motile sperm count, T, E(2), LH, FSH, and PRL. Result(s): Total motile sperm count was decreased in patients with increased beta-hCG (median 11.9 x 10(6)) compared with patients with normal beta-hCG (median 21.5 x 10(6)). Testosterone, E(2), and PRL were significantly higher in patients with increased beta-hCG levels, whereas LH and FSH were lower. Semen quality was significantly and negatively correlated with beta-hCG, E(2), and PRL. Conclusion(s): Patients with increased beta-hCG had an inferior spermatogenesis compared with patients with normal beta-hCG. Increased beta-hCG appears to be associated with impaired spermatogenesis and increased levels of E(2) and PRL. |
| المشرفين على المادة: | 0 (Chorionic Gonadotropin, beta Subunit, Human) 0 (alpha-Fetoproteins) 3XMK78S47O (Testosterone) 4TI98Z838E (Estradiol) 9002-62-4 (Prolactin) 9002-68-0 (Follicle Stimulating Hormone) |
| تواريخ الأحداث: | Date Created: 20080429 Date Completed: 20090708 Latest Revision: 20220321 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.fertnstert.2008.03.016 |
| PMID: | 18440530 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1556-5653 |
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| DOI: | 10.1016/j.fertnstert.2008.03.016 |