دورية أكاديمية
Biological monitoring of smoke exposure among wildland firefighters: a pilot study comparing urinary methoxyphenols with personal exposures to carbon monoxide, particular matter, and levoglucosan.
| العنوان: | Biological monitoring of smoke exposure among wildland firefighters: a pilot study comparing urinary methoxyphenols with personal exposures to carbon monoxide, particular matter, and levoglucosan. |
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| المؤلفون: | Neitzel R; Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195-7234, USA., Naeher LP, Paulsen M, Dunn K, Stock A, Simpson CD |
| المصدر: | Journal of exposure science & environmental epidemiology [J Expo Sci Environ Epidemiol] 2009 May; Vol. 19 (4), pp. 349-58. Date of Electronic Publication: 2008 Apr 30. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101262796 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-064X (Electronic) Linking ISSN: 15590631 NLM ISO Abbreviation: J Expo Sci Environ Epidemiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Nature Pub. Group, c2006- |
| مواضيع طبية MeSH: | Environmental Monitoring* , Fires* , Occupational Exposure* , Smoke*, Carbon Monoxide/*toxicity , Glucose/*analogs & derivatives , Phenols/*urine, Adult ; Creatinine/urine ; Glucose/toxicity ; Humans ; Particle Size ; Pilot Projects ; United States |
| مستخلص: | Urinary methoxyphenols (MPs) have been proposed as biomarkers of woodsmoke exposure. However, few field studies have been undertaken to evaluate the relationship between woodsmoke exposure and urinary MP concentrations. We conducted a pilot study at the US Forest Service-Savannah River Site, in which carbon monoxide (CO), levoglucosan (LG), and particulate matter (PM(2.5)) exposures were measured in wildland firefighters on prescribed burn days. Pre- and post-shift urine samples were collected from each subject, and cross-shift changes in creatinine-corrected urinary MP concentrations were calculated. Correlations between exposure measures and creatine-adjusted urinary MP concentrations were explored, and regression models were developed relating changes in urinary MP concentrations to measured exposure levels. Full-shift measurements were made on 13 firefighters over 20 work shifts in winter 2004 at the US Forest Service Savannah River site, a National Environmental Research Park. The average workshift length across the 20 measured shifts was 701+/-95 min. LG and CO exposures were significantly correlated for samples where the filter measurement captured at least 60% of the work shift (16 samples), as well as for the smaller set of full-shift exposure samples (n=9). PM(2.5) and CO exposures were not significantly correlated, and LG and PM(2.5) exposures were only significantly correlated for samples representing at least 60% of the work shift. Creatinine-corrected urinary concentrations for 20 of the 22 MPs showed cross-shift increases, with 14 of these changes showing statistical significance. Individual and summed creatinine-adjusted guaiacol urinary MPs were highly associated with CO (and, to a lesser degree, LG) exposure levels, and random-effects regression models including CO and LG exposure levels explained up to 80% of the variance in cross-shift changes in summed creatinine-adjusted guaiacol urinary MP concentrations. Although limited by the small sample size, this pilot study demonstrates that urinary MP concentrations may be effective biomarkers of occupational exposure to wood smoke among wildland firefighters. |
| معلومات مُعتمدة: | R03-OH007656 United States OH NIOSH CDC HHS |
| المشرفين على المادة: | 0 (Phenols) 0 (Smoke) 5132N17FSD (1,6-anhydro-beta-glucopyranose) 7U1EE4V452 (Carbon Monoxide) AYI8EX34EU (Creatinine) IY9XDZ35W2 (Glucose) |
| تواريخ الأحداث: | Date Created: 20080501 Date Completed: 20090702 Latest Revision: 20171116 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1038/jes.2008.21 |
| PMID: | 18446186 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1559-064X |
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| DOI: | 10.1038/jes.2008.21 |