دورية أكاديمية
[Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2006].
| العنوان: | [Nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2006]. |
|---|---|
| المؤلفون: | Yamaguchi K; Department of Microbiology and Infectious Diseases, Toho University School of Medicine., Ishii Y, Iwata M, Watanabe N, Uehara N, Yasujima M, Kasai T, Suwabe A, Yamahata K, Kaku M, Kanemitsu K, Imafuku Y, Nishiyama K, Murakami M, Yomoda S, Taniguchi N, Yamada T, Nomura F, Watanabe M, Kanno H, Aihara M, Maesaki S, Hashikita G, Kondo S, Misawa S, Horiuchi H, Tazawa Y, Nakashima H, Takemura H, Okada M, Yamazaki F, Horii T, Maekawa M, Baba H, Ishigo S, Fujita N, Komori T, Ichiyama S, Iinuma Y, Maeda S, Yamanaka K, Murata Y, Matsuo S, Kohno H, Kinoshita S, Fujita J, Negayama K, Murase M, Miyamoto H, Kusano N, Mihara E, Itaha H, Ono J, Yoshimura H, Yanagihara K, Matsuda J, Saikawa T, Hiramatsu K |
| المصدر: | The Japanese journal of antibiotics [Jpn J Antibiot] 2007 Dec; Vol. 60 (6), pp. 344-77. |
| نوع المنشور: | Journal Article |
| اللغة: | Japanese |
| بيانات الدورية: | Publisher: Japan Antibiotics Research Assn Country of Publication: Japan NLM ID: 0154402 Publication Model: Print Cited Medium: Print ISSN: 0368-2781 (Print) Linking ISSN: 03682781 NLM ISO Abbreviation: Jpn J Antibiot Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Tokyo, Japan Antibiotics Research Assn. |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Gram-Negative Bacteria/*drug effects , Gram-Positive Bacteria/*drug effects , Thienamycins/*pharmacology, Drug Resistance, Bacterial ; Gram-Negative Bacteria/enzymology ; Gram-Negative Bacteria/isolation & purification ; Gram-Negative Bacterial Infections/microbiology ; Gram-Positive Bacteria/enzymology ; Gram-Positive Bacteria/isolation & purification ; Gram-Positive Bacterial Infections/microbiology ; Humans ; Injections, Intravenous ; Japan ; Meropenem ; Time Factors ; beta-Lactamases/biosynthesis |
| مستخلص: | The antibacterial activity of meropenem (MEPM) and other parenteral antibiotics against clinical isolates of 876 strains of Gram-positive bacteria, 1764 strains of Gram-negative bacteria, and 198 strains of anaerobic bacteria obtained from 30 medical institutions during 2006 was measured. The results were as follows; 1. MEPM was more active than the other carbapenem antibiotics tested against Gram-negative bacteria, especially against enterobacteriaceae and Haemophilus influenzae. MEPM was also active against most of the species tested in Gram-positive and anaerobic bacteria, except for multi-drug resistant strains including methicillin-resistant Staphylococcus aureus. 2. As for Pseudomonas aeruginosa, all of the MEPM-resistant strains were resistant to imipenem (IPM). MEPM showed low cross-resistant rate both againt IPM-resistant P. aeruginosa (41.8%) and ciprofloxacin-resistant P. aeruginosa (33.3%). 3. The proportion of extended-spectrum beta-lactamase (ESBL) strains was 4.3% (6 strains) in Escherichia coli, 1.1% (1 strain) in Citrobacter freundii, 21.7% (5 strains) in Citrobacter koseri, 3.1% (4 strains) in Klebsiella pneumoniae, 3.3% (3 strains) in Enterobacter cloacae, 0.8% (1 strain) in Serratia marcescens, and 4.9% (2 strains) in Providencia spp. The proportion of metallo-beta-lactamase strains was 3.1% (10 strains) in P. aeruginosa. 4. Of all species tested, there were no species, which MIC90 of MEPM was more than 4-fold higher than those in our previous study. Therefore, there is almost no significant decrease in susceptibility of clinical isolates to meropenem. In conclusion, the results from this surveillance study suggest that MEPM retains its potent and broad antibacterial activity and therefore is a clinically useful carbapenem at present, 11 years after available for commercial use. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Thienamycins) EC 3.5.2.6 (beta-Lactamases) FV9J3JU8B1 (Meropenem) |
| تواريخ الأحداث: | Date Created: 20080502 Date Completed: 20080624 Latest Revision: 20181201 |
| رمز التحديث: | 20240628 |
| PMID: | 18447206 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0368-2781 |
|---|