دورية أكاديمية
Mechanisms of shock in hantavirus pulmonary syndrome.
| العنوان: | Mechanisms of shock in hantavirus pulmonary syndrome. |
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| المؤلفون: | Abel Borges A; Virology Research Unit, University of South of Santa Catarina (UNISUL), Tubarão, Santa Catarina State, Brazil. alessandra.borges@unisul.br, Figueiredo LT |
| المصدر: | Current opinion in infectious diseases [Curr Opin Infect Dis] 2008 Jun; Vol. 21 (3), pp. 293-7. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8809878 Publication Model: Print Cited Medium: Print ISSN: 0951-7375 (Print) Linking ISSN: 09517375 NLM ISO Abbreviation: Curr Opin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, Md. : Lippincott Williams & Wilkins Original Publication: London, UK ; Philadelphia, PA : Gower Academic Journals, c1988- |
| مواضيع طبية MeSH: | Hantavirus Pulmonary Syndrome/*complications , Shock, Cardiogenic/*immunology , Shock, Cardiogenic/*virology, Animals ; CD8-Positive T-Lymphocytes/immunology ; Cricetinae ; Hantavirus Pulmonary Syndrome/immunology ; Hantavirus Pulmonary Syndrome/virology ; Humans ; Mesocricetus ; Mice ; Models, Animal ; Myocarditis/virology |
| مستخلص: | Purpose of Review: Despite abundant literature on hantavirus, few reports have focused on the shock in hantavirus pulmonary syndrome. This review approaches recent advances that allow us to better understand the pathogenesis of hantavirus pulmonary syndrome shock. Recent Findings: Hantavirus pulmonary syndrome has been studied in a hamster model that mimics human shock and respiratory failure. In-vitro experiments show that pathogenic hantaviruses are able to inhibit antiviral responses, and that cytotoxicity of hantavirus-specific T cells enhances the permeability of infected endothelial cells. The idea that the primary cardiac lesion of shock is mostly functional has been shaken by the report of a typical myocarditis in hearts from human hantavirus pulmonary syndrome fatal cases. The involvement of regulatory T cells on hantavirus persistence in its rodent reservoir suggests that these cells could protect from severe hantavirus pulmonary syndrome and shock. Summary: Hantavirus pulmonary syndrome shock is probably related to an exacerbated immune response of CD8+ T cells producing cytotoxicity on infected endothelial cells, presence of myocarditis and myocardial depression induced by nitric oxide. The virulence elements in G1 glycoprotein could also contribute to shock. Active suppression of immune T regulatory cells is probably involved in hantavirus pulmonary syndrome pathogenesis. These are all new aspects of hantavirus pulmonary syndrome pathogenesis that stimulate further studies to elucidate mechanisms of shock and to develop effective treatment strategies. |
| Number of References: | 30 |
| تواريخ الأحداث: | Date Created: 20080502 Date Completed: 20081112 Latest Revision: 20080501 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/QCO.0b013e3282f88b6f |
| PMID: | 18448975 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0951-7375 |
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| DOI: | 10.1097/QCO.0b013e3282f88b6f |