دورية أكاديمية
Testosterone increases lipolysis and the number of beta-adrenoceptors in male rat adipocytes.
| العنوان: | Testosterone increases lipolysis and the number of beta-adrenoceptors in male rat adipocytes. |
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| المؤلفون: | Xu XF; Wallenberg Laboratory, Sahlgren's Hospital, University of Göteborg, Sweden., De Pergola G, Björntorp P |
| المصدر: | Endocrinology [Endocrinology] 1991 Jan; Vol. 128 (1), pp. 379-82. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Print ISSN: 0013-7227 (Print) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions, |
| مواضيع طبية MeSH: | Adipose Tissue/*metabolism , Isoproterenol/*pharmacology , Lipolysis/*drug effects , Receptors, Adrenergic, beta/*metabolism , Testosterone/*pharmacology, Adipose Tissue/drug effects ; Animals ; Cells, Cultured ; Iodocyanopindolol ; Kinetics ; Male ; Orchiectomy ; Pindolol/analogs & derivatives ; Pindolol/metabolism ; Rats ; Rats, Inbred Strains ; Receptors, Adrenergic, beta/drug effects ; Reference Values ; Up-Regulation |
| مستخلص: | The influence of androgen status on the regulation of lipolysis and number of beta-adrenoceptors in isolated adipocytes was studied in male rats. Castration resulted in decreased catecholamine-induced as well as forskolin-induced lipolysis. beta-adrenoceptor number, examined by a whole cell cyanopindolol binding assay, was also diminished to a similar extent. Testosterone treatment of castrated rats normalized lipolysis as well as beta-adrenoceptor number. These results demonstrate that testosterone stimulates catecholamine-induced lipolysis in vivo by increasing the number of beta-adrenoceptors as well as the activity of adenylate cyclase, confirming previous in vitro studies performed in adipose precursor cells. |
| المشرفين على المادة: | 0 (Receptors, Adrenergic, beta) 3XMK78S47O (Testosterone) 83498-72-0 (Iodocyanopindolol) BJ4HF6IU1D (Pindolol) L628TT009W (Isoproterenol) |
| تواريخ الأحداث: | Date Created: 19910101 Date Completed: 19910221 Latest Revision: 20131121 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1210/endo-128-1-379 |
| PMID: | 1846106 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0013-7227 |
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| DOI: | 10.1210/endo-128-1-379 |