دورية أكاديمية
أعرض في EDS

Controlling schistosomiasis: significant decrease of anaemia prevalence one year after a single dose of praziquantel in Nigerian schoolchildren.

التفاصيل البيبلوغرافية
العنوان: Controlling schistosomiasis: significant decrease of anaemia prevalence one year after a single dose of praziquantel in Nigerian schoolchildren.
المؤلفون: Tohon ZB; CERMES/Réseau International des Instituts Pasteur, Niamey, Niger. ztohon@cermes.org, Mainassara HB, Garba A, Mahamane AE, Bosqué-Oliva E, Ibrahim ML, Duchemin JB, Chanteau S, Boisier P
المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2008 May 28; Vol. 2 (5), pp. e241. Date of Electronic Publication: 2008 May 28.
نوع المنشور: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: Electronic Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Anemia/*etiology , Anthelmintics/*therapeutic use , Praziquantel/*therapeutic use , Schistosomiasis/*complications , Schistosomiasis/*drug therapy, Anemia/epidemiology ; Child ; Female ; Humans ; Male ; Nigeria ; Schistosomiasis/pathology ; Treatment Outcome
مستخلص: Background: In the framework of the monitoring and evaluation of the Nigerian schistosomiasis and soil-transmitted helminth control programme, a follow-up of children took place in eight sentinel sites. The objective of the study was to assess the evolution of Schistosoma haematobium infection and anaemia in schoolchildren after a single administration of praziquantel (PZQ) and albendazole.
Methods/principal Findings: Pre-treatment examination and follow-up at one year post-treatment of schoolchildren aged 7, 8, and 11 years, including interview, urine examination, ultrasound examination of the urinary tract, and measurement of haemoglobin. Before treatment, the overall prevalence of S. heamatobium infection was 75.4% of the 1,642 enrolled children, and 21.8% of children excreted more than 50 eggs/10 ml urine. Prevalence increased with age. The overall prevalence of anaemia (haemoglobin <11.5 g/dl) was 61.6%, decreasing significantly with increasing age. The mean haemoglobinemia was 11 g/dl. In bivariate analysis, anaemia was significantly more frequent in children infected with S. haematobium, although it was not correlated to the intensity of infection. Anaemia was also associated with micro-haematuria and to kidney distensions. In a sub-sample of 636 children tested for P. falciparum infection, anaemia was significantly more frequent in malaria-infected children. In multivariate analysis, significant predictors of anaemia were P. falciparum infection, kidney distension, and the village. One year after a single-dose praziquantel treatment (administered using the WHO PZQ dose pole) co-administered with albendazole (400 mg single dose) for de-worming, the prevalence of S. haematobium infection was 38%, while the prevalence of anaemia fell to 50.4%. The mean haemoglobinemia showed a statistically significant increase of 0.39 g/dl to reach 11.4 g/dl. Anaemia was no longer associated with S. haematobium or to P. falciparum infections, or to haematuria or ultrasound abnormalities of the urinary tract.
Conclusions: The high prevalence of anaemia in Nigerian children is clearly a result of many factors and not of schistosomiasis alone. Nevertheless, treatment of schistosomiasis and de-worming were followed by a partial, but significant, reduction of anaemia in schoolchildren, not explainable by any other obvious intervention.
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المشرفين على المادة: 0 (Anthelmintics)
6490C9U457 (Praziquantel)
تواريخ الأحداث: Date Created: 20080530 Date Completed: 20100309 Latest Revision: 20211020
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC2386241
DOI: 10.1371/journal.pntd.0000241
PMID: 18509472
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-2735
DOI:10.1371/journal.pntd.0000241