دورية أكاديمية
أعرض في EDS

Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells.

التفاصيل البيبلوغرافية
العنوان: Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells.
المؤلفون: Dejosez M; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA., Krumenacker JS, Zitur LJ, Passeri M, Chu LF, Songyang Z, Thomson JA, Zwaka TP
المصدر: Cell [Cell] 2008 Jun 27; Vol. 133 (7), pp. 1162-74.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge, Ma : Cell Press
Original Publication: Cambridge, MIT Press.
مواضيع طبية MeSH: Embryonic Development*, DNA-Binding Proteins/*metabolism , Embryonic Stem Cells/*cytology , Pluripotent Stem Cells/*cytology, Animals ; Cell Differentiation ; Cell Line ; DNA-Binding Proteins/genetics ; Embryo Implantation ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Gene Expression ; Genes, Lethal ; Host Cell Factor C1/metabolism ; Mice ; Repressor Proteins ; Two-Hybrid System Techniques
مستخلص: Pluripotency is a unique biological state that allows cells to differentiate into any tissue type. Here we describe a candidate pluripotency factor, Ronin, that possesses a THAP domain, which is associated with sequence-specific DNA binding and epigenetic silencing of gene expression. Ronin is expressed primarily during the earliest stages of murine embryonic development, and its deficiency in mice produces periimplantational lethality and defects in the inner cell mass. Conditional knockout of Ronin prevents the growth of ES cells while forced expression of Ronin allows ES cells to proliferate without differentiation under conditions that normally do not promote self-renewal. Ectopic expression also partly compensates for the effects of Oct4 knockdown. We demonstrate that Ronin binds directly to HCF-1, a key transcriptional regulator. Our findings identify Ronin as an essential factor underlying embryogenesis and ES cell pluripotency. Its association with HCF-1 suggests an epigenetic mechanism of gene repression in pluripotent cells.
التعليقات: Erratum in: Cell. 2008 Aug 22;134(4):692.
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معلومات مُعتمدة: T32 HL092332-06 United States HL NHLBI NIH HHS; 5T32DK060445 United States DK NIDDK NIH HHS; T32 HL092332 United States HL NHLBI NIH HHS; P01 GM081627 United States GM NIGMS NIH HHS; P01 GM081627-010004 United States GM NIGMS NIH HHS; P20 EB007076 United States EB NIBIB NIH HHS; R01 EB005173 United States EB NIBIB NIH HHS; R01 GM077442 United States GM NIGMS NIH HHS; P01 GM81627 United States GM NIGMS NIH HHS; R01 EB005173-01 United States EB NIBIB NIH HHS
المشرفين على المادة: 0 (DNA-Binding Proteins)
0 (Host Cell Factor C1)
0 (Repressor Proteins)
0 (Thap11 protein, mouse)
تواريخ الأحداث: Date Created: 20080701 Date Completed: 20080716 Latest Revision: 20220409
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC2495776
DOI: 10.1016/j.cell.2008.05.047
PMID: 18585351
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4172
DOI:10.1016/j.cell.2008.05.047