دورية أكاديمية
أعرض في EDS

Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice.

التفاصيل البيبلوغرافية
العنوان: Estrous cycle regulates activation of hippocampal Akt, LIM kinase, and neurotrophin receptors in C57BL/6 mice.
المؤلفون: Spencer JL; Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10065, USA. spencej@rockfeller.edu, Waters EM, Milner TA, McEwen BS
المصدر: Neuroscience [Neuroscience] 2008 Sep 09; Vol. 155 (4), pp. 1106-19. Date of Electronic Publication: 2008 Jun 08.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0306-4522 (Print) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
مواضيع طبية MeSH: Estrous Cycle/*physiology , Hippocampus/*metabolism , Lim Kinases/*metabolism , Maze Learning/*physiology , Oncogene Protein v-akt/*metabolism , Receptors, Nerve Growth Factor/*metabolism, Analysis of Variance ; Animals ; Behavior, Animal ; Disks Large Homolog 4 Protein ; Estradiol/metabolism ; Female ; Gene Expression Regulation/physiology ; Guanylate Kinases ; Hippocampus/anatomy & histology ; Intracellular Signaling Peptides and Proteins/metabolism ; Maze Learning/drug effects ; Membrane Proteins/metabolism ; Mice ; Mice, Inbred C57BL ; Progesterone/metabolism ; Synaptophysin/metabolism
مستخلص: Estradiol modulates dendritic spine morphology and synaptic protein expression in the rodent hippocampus, as well as hippocampal-dependent learning and memory. In the rat, these effects may be mediated through nongenomic steroid signaling such as estradiol activation of the Akt and LIM kinase (LIMK) pathways, in addition to genomic signaling involving estradiol upregulation of brain-derived neurotrophic factor expression (BDNF). Due to the many species differences between mice and rats, including differences in the hippocampal response to estradiol, it is unclear whether estradiol modulates these pathways in the mouse hippocampus. Therefore, we investigated whether endogenous fluctuations of gonadal steroids modulate hippocampal activation of the Akt, LIMK, and the BDNF receptor TrkB in conjunction with spatial memory in female C57BL/6 mice. We found that Akt, LIMK, and TrkB were activated throughout the dorsal hippocampal formation during the high-estradiol phase, proestrus. Cycle phase also modulated expression of the pre- and post-synaptic markers synaptophysin and post-synaptic density 95. However, cycle phase did not influence performance on an object placement test of spatial memory, although this task is known to be sensitive to the complete absence of ovarian hormones. The findings suggest that endogenous estradiol and progesterone produced by the ovaries modulate specific signaling pathways governing actin remodeling, cell excitability, and synapse formation.
التعليقات: Erratum in: Neuroscience. 2009 Sep 15;162(4):1437.
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معلومات مُعتمدة: R01 DA008259-14 United States DA NIDA NIH HHS; R01 NS007080 United States NS NINDS NIH HHS; GM07739 United States GM NIGMS NIH HHS; NS007080 United States NS NINDS NIH HHS; R01 DA008259 United States DA NIDA NIH HHS; P01 HL018974-309002 United States HL NHLBI NIH HHS; F30 MH082528 United States MH NIMH NIH HHS; R01 NS007080-41 United States NS NINDS NIH HHS; P01 HL018974-299002 United States HL NHLBI NIH HHS; F30 MH082528-01 United States MH NIMH NIH HHS; P01 HL018974-300022 United States HL NHLBI NIH HHS; F30 MH082528-02 United States MH NIMH NIH HHS; R01 DA008259-15 United States DA NIDA NIH HHS; DA08259 United States DA NIDA NIH HHS; HL18974 United States HL NHLBI NIH HHS; F32 DK117510 United States DK NIDDK NIH HHS; P01 HL018974 United States HL NHLBI NIH HHS; MH082528 United States MH NIMH NIH HHS; R01 NS007080-40 United States NS NINDS NIH HHS; P01 HL018974-290022 United States HL NHLBI NIH HHS; T32 GM007739 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (Disks Large Homolog 4 Protein)
0 (Dlg4 protein, mouse)
0 (Intracellular Signaling Peptides and Proteins)
0 (Membrane Proteins)
0 (Receptors, Nerve Growth Factor)
0 (Synaptophysin)
4G7DS2Q64Y (Progesterone)
4TI98Z838E (Estradiol)
EC 2.7.11.1 (Lim Kinases)
EC 2.7.11.1 (Oncogene Protein v-akt)
EC 2.7.4.8 (Guanylate Kinases)
تواريخ الأحداث: Date Created: 20080708 Date Completed: 20090206 Latest Revision: 20221219
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC2621322
DOI: 10.1016/j.neuroscience.2008.05.049
PMID: 18601981
قاعدة البيانات: MEDLINE
الوصف
تدمد:0306-4522
DOI:10.1016/j.neuroscience.2008.05.049