دورية أكاديمية
أعرض في EDS

RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.

التفاصيل البيبلوغرافية
العنوان: RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.
المؤلفون: Oh SD; Department of Microbiology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA., Lao JP, Taylor AF, Smith GR, Hunter N
المصدر: Molecular cell [Mol Cell] 2008 Aug 08; Vol. 31 (3), pp. 324-36.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge Ma : Cell Press
Original Publication: Cambridge, Mass. : Cell Press, c1997-
مواضيع طبية MeSH: Meiosis*, DNA-Binding Proteins/*metabolism , Endonucleases/*metabolism , RecQ Helicases/*metabolism , Recombination, Genetic/*genetics , Saccharomyces cerevisiae/*cytology , Saccharomyces cerevisiae/*enzymology , Saccharomyces cerevisiae Proteins/*metabolism , Trans-Activators/*metabolism, Chromosome Segregation ; Crossing Over, Genetic/genetics ; Cyclin B/metabolism ; DNA Breaks, Double-Stranded ; DNA, Cruciform/ultrastructure ; Flap Endonucleases ; Mutation/genetics ; Time Factors
مستخلص: Saccharomyces cerevisiae RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, are implicated in processing joint molecule (JM) recombination intermediates. We show that cells lacking either enzyme frequently experience chromosome segregation problems during meiosis and that when both enzymes are absent attempted segregation fails catastrophically. In all cases, segregation appears to be impeded by unresolved JMs. Analysis of the DNA events of recombination indicates that Sgs1 limits aberrant JM structures that result from secondary strand-invasion events and often require Mus81-Mms4 for their normal resolution. Aberrant JMs contain high levels of single Holliday junctions and include intersister JMs, multichromatid JMs comprising three and four chromatids, and newly identified recombinant JMs containing two chromatids, one of which has undergone crossing over. Despite persistent JMs in sgs1 mms4 double mutants, crossover and noncrossover products still form at high levels. We conclude that Sgs1 and Mus81-Mms4 collaborate to eliminate aberrant JMs, whereas as-yet-unidentified enzymes process normal JMs.
References: Curr Biol. 2004 Jan 20;14(2):R56-8. (PMID: 14738748)
Genetics. 2003 May;164(1):81-94. (PMID: 12750322)
Genes Dev. 2000 Feb 15;14(4):493-503. (PMID: 10691741)
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3757-62. (PMID: 18310322)
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16887-92. (PMID: 12475932)
Cell. 1995 Dec 1;83(5):783-91. (PMID: 8521495)
Genetics. 2003 Dec;165(4):2289-93. (PMID: 14704204)
Cell. 2004 Apr 2;117(1):29-45. (PMID: 15066280)
Mol Cell. 2008 Feb 29;29(4):517-24. (PMID: 18313389)
Cytogenet Genome Res. 2004;107(3-4):201-7. (PMID: 15467365)
PLoS Genet. 2006 Sep 22;2(9):e155. (PMID: 17002499)
Genetics. 2001 Jan;157(1):103-18. (PMID: 11139495)
Cell. 2001 Jul 13;106(1):59-70. (PMID: 11461702)
Science. 2003 Apr 18;300(5618):482-6. (PMID: 12663816)
Anal Biochem. 1983 Apr 15;130(2):527-35. (PMID: 6869840)
Cell. 2006 Dec 15;127(6):1167-78. (PMID: 17174892)
Cell. 2001 Nov 16;107(4):537-48. (PMID: 11719193)
Mol Gen Genet. 2000 Jun;263(5):812-27. (PMID: 10905349)
Genetics. 2001 Dec;159(4):1511-25. (PMID: 11779793)
Cell. 2001 Jul 13;106(1):47-57. (PMID: 11461701)
PLoS Biol. 2007 Nov 6;5(11):e299. (PMID: 17988174)
Genes Dev. 2004 Jan 15;18(2):117-25. (PMID: 14752007)
Nat Cell Biol. 2003 May;5(5):480-5. (PMID: 12717442)
Microbiol Mol Biol Rev. 1999 Jun;63(2):349-404. (PMID: 10357855)
Nature. 1997 Mar 27;386(6623):414-7. (PMID: 9121560)
Mol Cell Biol. 1995 Dec;15(12):6572-81. (PMID: 8524222)
EMBO J. 2002 Oct 15;21(20):5577-85. (PMID: 12374758)
Genet Res. 2007 Dec;89(5-6):285-307. (PMID: 18976517)
Nature. 2005 Aug 18;436(7053):1053-7. (PMID: 16107854)
Cell. 2000 Oct 27;103(3):387-98. (PMID: 11081626)
DNA Repair (Amst). 2005 Feb 3;4(2):243-51. (PMID: 15590332)
Mol Cell. 2001 Jul;8(1):225-31. (PMID: 11511375)
Cell. 1990 Jun 15;61(6):1089-101. (PMID: 2190690)
Curr Biol. 2006 Mar 21;16(6):R217-28. (PMID: 16546077)
EMBO J. 2007 Apr 4;26(7):1891-901. (PMID: 17363897)
Nucleic Acids Res. 2008 Apr;36(7):2182-95. (PMID: 18281703)
Genetics. 2006 Dec;174(4):1745-54. (PMID: 17028345)
Cell. 2004 Apr 2;117(1):9-15. (PMID: 15066278)
Mol Cell Biol. 1993 Jan;13(1):373-82. (PMID: 8417336)
EMBO J. 2005 Jun 1;24(11):2024-33. (PMID: 15889139)
Nature. 2003 Dec 18;426(6968):870-4. (PMID: 14685245)
Genes Dev. 2001 Oct 15;15(20):2730-40. (PMID: 11641278)
Mol Cell. 2008 Aug 8;31(3):313-23. (PMID: 18691964)
Cell. 1991 Sep 20;66(6):1239-56. (PMID: 1913808)
Mol Cell Biol. 1994 Mar;14(3):1613-25. (PMID: 8114699)
Genetics. 2000 Mar;154(3):1101-14. (PMID: 10757756)
Cell. 1983 May;33(1):25-35. (PMID: 6380756)
Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4068-73. (PMID: 16537486)
Mutat Res. 2007 Dec 1;625(1-2):1-19. (PMID: 17555773)
Biochemistry. 2000 Nov 28;39(47):14617-25. (PMID: 11087418)
Mol Cell Biol. 2005 Jun;25(11):4476-87. (PMID: 15899853)
Cell. 2007 Jul 27;130(2):259-72. (PMID: 17662941)
Mol Cell Biol. 2003 May;23(10):3487-96. (PMID: 12724407)
معلومات مُعتمدة: R01 GM031693-25 United States GM NIGMS NIH HHS; GM031693 United States GM NIGMS NIH HHS; R01 GM074223-04 United States GM NIGMS NIH HHS; GM74223 United States GM NIGMS NIH HHS; R01 GM031693 United States GM NIGMS NIH HHS; R56 GM031693 United States GM NIGMS NIH HHS; R01 GM074223 United States GM NIGMS NIH HHS
المشرفين على المادة: 0 (CLB2 protein, S cerevisiae)
0 (Cyclin B)
0 (DNA, Cruciform)
0 (DNA-Binding Proteins)
0 (Saccharomyces cerevisiae Proteins)
0 (Trans-Activators)
EC 3.1.- (Endonucleases)
EC 3.1.- (Flap Endonucleases)
EC 3.1.- (MUS81 protein, S cerevisiae)
EC 3.1.22.- (MMS4 protein, S cerevisiae)
EC 3.6.1.- (SGS1 protein, S cerevisiae)
EC 3.6.4.12 (RecQ Helicases)
تواريخ الأحداث: Date Created: 20080812 Date Completed: 20080905 Latest Revision: 20240312
رمز التحديث: 20240312
مُعرف محوري في PubMed: PMC2587322
DOI: 10.1016/j.molcel.2008.07.006
PMID: 18691965
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-4164
DOI:10.1016/j.molcel.2008.07.006